ROLE OF CENTRAL CHOLINERGIC NEURONS IN EXPERIMENTAL-HYPERTENSION
ROLE OF CENTRAL CHOLINERGIC NEURONS IN EXPERIMENTAL-HYPERTENSION
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DOI：
10.1097/00005344-198007000-00002
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发表时间：
1980-01-01
影响因子：
3
通讯作者：
SPECTOR, S
中科院分区：
文献类型：
--
作者：
BUCCAFUSCO, JJ;SPECTOR, S
静脉注射胆碱酯酶抑制剂毒扁豆碱可引起12~14周龄自发性高血压大鼠(−)的高血压反应。与正常血压的Wistar-京都(WKY)对照组大鼠的类似注射相比，这些反应的幅度大大增强。用二甲基苯基哌嗪(DMPP)刺激自主神经节也可引起SHR的升压反应，但其幅度与WKY无明显差异。在未麻醉、自由活动的自发性高血压大鼠，侧脑室注射半乳糖-3(HC-3)阻断脑乙酰胆碱(ACh)的合成，产生明显的降压反应。在WKY注射类似的HC-3后，没有观察到动脉压下降。ICV HC-3后动脉压的下降与最初脑ACh水平的下降有关，尤其是在下丘脑。这些结果表明，青年自发性高血压患者的交感神经活动增强和由此导致的高血压状态依赖于中枢胆碱能活动的增加。
Intravenous injection of the cholinesterase inhibitor physostigmine evoked a hypertensive response in the unanesthetized 12− to 14-week-old spontaneously hypertensive rat (SHR). These responses were greatly enhanced in magnitude when compared to similar injections in normotensive Wistar-Kyoto (WKY) control rats. Stimulation of autonomic ganglia with dimethylphenylpiperazinium (DMPP) also evoked a pressor response in SHR; however, the magnitude of these responses was not different from those obtained in WKY. In unanesthetized, freely moving SHR, the intracerebroventricular (icv) injection of hemicholinium-3 (HC-3) to block the synthesis of brain acetylcholine (ACh) produced a marked hypotensive response. No reduction in arterial pressure was observed following similar injections of HC-3 in WKY. The decline in arterial pressure following icv HC-3 was correlated with the initial decline in brain ACh levels, particularly in the hypothalamus. These results indicate that enhanced sympathetic nerve activity and the resultant hypertensive state present in young SHR is dependent on increased central cholinergic activity.