Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2011.07.003
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发表时间：
2012-09-01
影响因子：
4.2
通讯作者：
Barkhof, Frederik
中科院分区：
文献类型：
--
作者：
Binnewijzend, Maja A. A.;Schoonheim, Menno M.;Barkhof, Frederik
采用静息态功能磁共振成像（rs-fMRI）研究了39例阿尔茨海默病（AD）患者、23例轻度认知功能障碍（MCI）患者和43例健康老年人的脑功能连接（FC）。平均随访2.8 ± 1.9年后，7例MCI患者转为AD，14例患者认知功能保持稳定。静息状态下的功能磁共振成像扫描进行了分析，使用独立成分分析（伊卡），其次是“双回归”技术，以创建和比较每个独立的时空组成部分的主题特定的地图，纠正年龄，性别和灰质萎缩。与对照组相比，AD患者楔前叶和后扣带回皮质的默认模式网络（DMN）内的FC较低，与皮质萎缩无关。MCI患者局部FC值在AD组与对照组之间无显著性差异，但仅AD组与稳定期MCI组之间差异有统计学意义。与认知功能障碍的相关性证明了DMN内FC变化的临床相关性。总之，在AD中观察到DMN内具有临床意义的FC降低。(C)2012 Elsevier Inc. All rights reserved.
Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied using resting-state functional magnetic resonance imaging (rs-fMRI). After a mean follow-up of 2.8 +/- 1.9 years, 7 MCI patients converted to AD, while 14 patients remained cognitively stable. Resting-state functional magnetic resonance imaging scans were analyzed using independent component analysis (ICA), followed by a "dual-regression" technique to create and compare subject-specific maps of each independent spatiotemporal component, correcting for age, sex, and gray matter atrophy. AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. Regional FC values of MCI patients were numerically in between AD patients and controls, but only the difference between AD and stable MCI patients was statistically significant. Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD. (C) 2012 Elsevier Inc. All rights reserved.