The Teleost Retina as a Model for Developmental and Regeneration Biology
The Teleost Retina as a Model for Developmental and Regeneration Biology
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DOI：
10.1089/zeb.2004.1.257
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发表时间：
2004-01-01
期刊：
影响因子：
2
通讯作者：
Raymond, Pamela A.
中科院分区：
文献类型：
--
作者：
Hitchcock, Peter F.;Raymond, Pamela A.
硬骨鱼类视网膜的发育大致可分为三个时期。第一个是在幼虫前脑细胞域的规范，引起视网膜原基和经历早期形态发生运动。第二个是视网膜内的神经源性事件增殖，细胞命运的决定，和图案的形成，建立神经元的身份，形成视网膜板层和细胞镶嵌。第三种是硬骨鱼特有的，发生在功能正常的眼睛中，是视网膜的拉伸和持续的神经发生，使视网膜的生长与眼睛和其他组织的生长保持同步。前两个事件是快速的，在斑马鱼胚胎中受精后约3天完成。第三种是终身的，占视网膜生长的大部分和成年视网膜神经元的绝大多数。此外，但显然与视网膜的发育史有关，杀死视网膜神经元的病变引起源自视网膜固有细胞的强大神经元再生。本文综述了硬骨鱼类视网膜发育的最新研究进展，重点介绍了胚胎期视网膜发育的遗传和分子调控、幼体和成体视网膜神经发生以及损伤诱导的神经元再生。
Retinal development in teleosts can broadly be divided into three epochs. The first is the specification of cellular domains in the larval forebrain that give rise to the retinal primordia and undergo early morphogenetic movements. The second is the neurogenic events within the retina proper-proliferation, cell fate determination, and pattern formation-that establish neuronal identities and form retinal laminae and cellular mosaics. The third, which is unique to teleosts and occurs in the functioning eye, is stretching of the retina and persistent neurogenesis that allows the growth of the retina to keep pace with the growth of the eye and other tissues. The first two events are rapid, complete by about 3 days postfertilization in the zebrafish embryo. The third is life-long and accounts for the bulk of retinal growth and the vast majority of adult retinal neurons. In addition, but clearly related to the retina's developmental history, lesions that kill retinal neurons elicit robust neuronal regeneration that originates from cells intrinsic to the retina. This paper reviews recent studies of retinal development in teleosts, focusing on those that shed light on the genetic and molecular regulation of retinal specification and morphogenesis in the embryo, retinal neurogenesis in larvae and adults, and injury-induced neuronal regeneration.