Association between reduced expression of hippocampal glucocorticoid receptors and cognitive dysfunction in a rat model of traumatic brain injury due to lateral head acceleration
Association between reduced expression of hippocampal glucocorticoid receptors and cognitive dysfunction in a rat model of traumatic brain injury due to lateral head acceleration
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侧向头部加速导致的创伤性脑损伤大鼠模型中海马糖皮质激素受体表达减少与认知功能障碍之间的关联
DOI：
10.1016/j.neulet.2012.11.020
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发表时间：
2013-01-15
影响因子：
2.5
通讯作者：
He, Xiaosheng
中科院分区：
文献类型：
--
作者：
Gao, Wei;Xu, Hongyu;He, Xiaosheng
观察大鼠头外侧加速致弥漫性创伤性脑损伤(TBI)后海马糖皮质激素受体(GRs)的表达及空间学习记忆能力，探讨GRs表达与认知功能障碍的关系。免疫组织化学染色、Western blotting和RT-PCR结果显示，脑创伤大鼠海马区GRs表达下调，表现为Morris水迷宫学习记忆能力下降。随着GRs表达的反弹，认知功能接近正常。结论：脑创伤大鼠学习记忆障碍与海马区GRs表达减少密切相关。海马区GRs参与了脑创伤后认知功能障碍的生化机制。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Expression of hippocampal glucocorticoid receptors (GRs) and spatial learning and memory were observed in rat model of diffuse traumatic brain injury (TBI) due to lateral head acceleration with an aim at investigating the relation between GRs expression and cognitive deficits. Immunohistochemical staining, Western blotting, and RT-PCR indicated that down-regulation of GRs expression occurred in the hippocampus among TBI-rats which demonstrated reduced performance of learning and memory in Morris water maze. As the GRs expression bounced up, the cognitive function approached to normal. It is concluded that reduced expression of hippocampal GRs was closely associated with learning and memory deficits in TBI-rats. Hippocampal GRs was involved in the biochemical mechanisms of cognitive deficits after TBI. (c) 2012 Elsevier Ireland Ltd. All rights reserved.