Caffeine's Vascular Mechanisms of Action.
Caffeine's Vascular Mechanisms of Action.
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DOI：
10.1155/2010/834060
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发表时间：
2010
影响因子：
1.3
通讯作者：
Prieto A
中科院分区：
文献类型：
--
作者：
Echeverri D;Montes FR;Cabrera M;Galán A;Prieto A
咖啡因是世界上消费最广泛的刺激物质。它存在于咖啡、茶、软饮料、巧克力和许多药物中。咖啡因是一种黄嘌呤，在血管组织中具有多种作用和作用机制。在内皮细胞中，它通过内皮一氧化氮合酶的表达增加细胞内钙刺激一氧化氮的产生。一氧化氮扩散到血管平滑肌细胞，产生血管舒张作用。在血管平滑肌细胞中，其作用主要是竞争性抑制磷酸二酯酶，产生 cAMP 积累和血管舒张。此外，它还阻断血管组织中存在的腺苷受体以产生血管收缩。本文描述了咖啡因对血管组织的主要作用机制，其中表明咖啡因具有一些心血管特性和作用，可以认为是有益的。
Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.