Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases
Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases
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DOI：
10.1016/j.gassur.2005.08.016
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发表时间：
2005-11-01
影响因子：
3.2
通讯作者：
Montorsi, M
中科院分区：
文献类型：
--
作者：
Torzilli, G;Del Fabbro, D;Montorsi, M
初步报告显示，对比增强术中超声检查（CEIOUS）提供了传统术中超声检查（IOUS）无法获得的有关肝脏原发性或转移性肿瘤的信息。本研究验证了 CEIOUS 的影响，重点关注结直肠癌 (CRC) 肝转移的切除手术。连续 24 名患者使用 IOUS 和 CEIOUS 因 CRC 肝转移接受了肝切除术。 CEIOUS 是通过静脉注射 4.8 mL 六氟化硫微泡来完成的。 CEIOUS 在 4 名患者的术前成像和 IOUS 中发现了遗漏的病灶，并证实了 4 名患者中 IOUS 的所有新发现。此外，CEIOUS 帮助确定了 29% CRC 肝转移患者主要病灶的肿瘤边缘。没有观察到与 CEIOUS 有关的副作用。总之，CEIOUS 提高了 IOUS 的准确性，对接受 CRC 肝转移手术的患者的手术策略和激进性产生重大影响。
Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29% of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.