ERYTHROCYTES AS CARRIERS FOR L-ASPARAGINASE - METHODOLOGICAL AND MOUSE INVIVO STUDIES
ERYTHROCYTES AS CARRIERS FOR L-ASPARAGINASE - METHODOLOGICAL AND MOUSE INVIVO STUDIES
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DOI：
10.1111/j.2042-7158.1990.tb06598.x
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发表时间：
1990-07-01
影响因子：
3.3
通讯作者：
CHASSAIGNE, M
中科院分区：
文献类型：
--
作者：
KRAVTZOFF, R;ROPARS, C;CHASSAIGNE, M
L-Asparaginase has been encapsulated in Swiss mouse or human erythrocytes by hypotonic haemolysis followed by isotonic resealing and reannealing. The details of incorporation and properties of carrier erythrocytes are presented. When L-asparaginase loaded into 51Cr-labelled erythrocytes, was infused intravenously, the same half-life was found for asparaginase and 51Cr. In addition, L-asparaginase loaded into erythrocytes was much more effective in eliminating plasma asparagine compared with the same dose of free L-asparginase injected in solution, during a sustained period (14 days).
