On the origin of differentiation
On the origin of differentiation
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DOI：
10.1007/bf02705126
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发表时间：
2003-06-01
影响因子：
2.9
通讯作者：
Bonner, JT
中科院分区：
文献类型：
--
作者：
Bonner, JT
在许多原始生物体的多细胞起源之后，进化出不止一种细胞类型。人们一直认为这种早期分化与大小有关--有机体越大，细胞类型就越多。这里考虑了两种非常不同的生物：通过生长成为多细胞的Volvocine藻类，以及通过聚集成为多细胞的细胞黏菌。在这两种情况下，有些物种只有一种细胞类型，而另一些物种则有两种细胞类型。已经有可能证明这与大小存在完美的相关性：具有两种细胞类型的表格明显大于具有一种细胞类型的表格。此外，在两组中都有中等大小的形式，根据个体的大小从一种到两种细胞类型不等，这表明了一种群体感应的形式。这些观察结果强化了这样一种观点，即大小在影响分化程度方面起着关键作用。
Following the origin of multicellularity in many groups of primitive organisms there evolved more than one cell type. It has been assumed that this early differentiation is related to size - the larger the organism the more cell types. Here two very different kinds of organisms are considered: the volvocine algae that become multicellular by growth, and the cellular slime moulds that become multicellular by aggregation. In both cases there are species that have only one cell type and others that have two. It has been possible to show that there is a perfect correlation with size: the forms with two cell types are significantly larger-than those with one. Also in both groups there are forms of intermediate size that will vary from one to two cell types depending on the size of the individuals, suggesting a form of quorum sensing. These observations reinforce the view that size plays a critical role in influencing the degree of differentiation.