PROCESS-DEVELOPMENT FOR THE PRODUCTION OF RECOMBINANT ANTIBODIES USING THE GLUTAMINE-SYNTHETASE (GS) SYSTEM
PROCESS-DEVELOPMENT FOR THE PRODUCTION OF RECOMBINANT ANTIBODIES USING THE GLUTAMINE-SYNTHETASE (GS) SYSTEM
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DOI：
10.1007/bf02521750
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发表时间：
1992-01-01
期刊：
影响因子：
2.2
通讯作者：
HASSELL, T
中科院分区：
文献类型：
--
作者：
BROWN, ME;RENNER, G;HASSELL, T
结论GS技术已成功用于重组抗体的表达。所述载体能够在大规模生产所需的延长时间内稳定地积累产物。已经开发了大规模的方法，得到了高达，在一种情况下超过1g/l的极高的抗体产率。很明显，这种系统代表了对先前技术的重大进步，并将加速这种治疗产品的商业应用。
ConclusionsGS technology has been successfully utilised for the expression of recombinant antibodies. The vectors are capable of stable product accumulation over the extended periods required for large scale manufacture. Large scale processes have been developed giving extremely high antibody yields up to, and in one instance in excess of 1 g/l. It is clear that such systems represent a significant advance over previous technology and will speed the commercial application of such therapeutic products.