Associations of perceived norms with intentions to learn genomic sequencing results: Roles for attitudes and ambivalence.
Associations of perceived norms with intentions to learn genomic sequencing results: Roles for attitudes and ambivalence.
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感知规范与学习基因组测序结果意图的关联：态度和矛盾心理的作用。
DOI：
10.1037/hea0000579
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Klein,WilliamMP
中科院分区：
文献类型：
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作者：
Reid,AlleciaE;Taber,JenniferM;Ferrer,RebeccaA;Biesecker,BarbaraB;Lewis,KatieL;Biesecker,LeslieG;Klein,WilliamMP
目的基因组测序正变得越来越容易获得，强调需要了解驱动接受检测结果的社会和心理因素。这些决定可能依赖于可感知的描述性规范（大多数人的行为）和禁令性规范（他人认可的行为）。我们预测描述性规范将与学习基因组测序结果的意图直接相关，而禁令规范将通过态度间接相关。假设当个体对获得结果持矛盾态度时，意图与态度之间的差异联系最为强烈。方法参加基因组测序试验的参与者（n= 372）报告了了解医学上可操作、非医学上可操作和载体测序结果的意图。描述性规范项目参考了其他研究参与者。分别对亲密朋友和家庭成员的禁令规范进行分析。态度、态度矛盾心理和社会人口学协变量也被评估。结果在结构方程模型中，描述性规范和朋友禁令规范都与接受所有测序结果的意愿相关(ps<。004)。态度一致地介导了所有的朋友禁令规范-意图关联，但不介导描述性规范-意图关联。态度矛盾心理调节了朋友命令规范之间的关联(p≤。001)，但没有描述性规范(p=。16)、态度。当矛盾心理高时，禁令规范与态度显著相关，而当矛盾心理低时，禁令规范与态度不相关。结果与家庭禁令规范相同。结论描述性规范和禁令性规范在基因组测序决策中起作用。考虑到这些过程的中介和调节者，可以提高优化使用规范信息的能力，以支持知情决策。
ObjectiveGenomic sequencing is becoming increasingly accessible, highlighting the need to understand the social and psychological factors that drive interest in receiving testing results. These decisions may depend on perceived descriptive norms (how most others behave) and injunctive norms (what is approved of by others). We predicted that descriptive norms would be directly associated with intentions to learn genomic sequencing results, whereas injunctive norms would be associated indirectly, via attitudes. These differential associations with intentions versus attitudes were hypothesized to be strongest when individuals held ambivalent attitudes toward obtaining results.MethodParticipants enrolled in a genomic sequencing trial (n= 372) reported intentions to learn medically actionable, nonmedically actionable, and carrier sequencing results. Descriptive norms items referenced other study participants. Injunctive norms were analyzed separately for close friends and family members. Attitudes, attitudinal ambivalence, and sociodemographic covariates were also assessed.ResultsIn structural equation models, both descriptive norms and friend injunctive norms were associated with intentions to receive all sequencing results (ps<. 004). Attitudes consistently mediated all friend injunctive norms-intentions associations, but not the descriptive norms–intentions associations. Attitudinal ambivalence moderated the association between friend injunctive norms (p≤. 001), but not descriptive norms (p=. 16), and attitudes. Injunctive norms were significantly associated with attitudes when ambivalence was high, but were unrelated when ambivalence was low. Results replicated for family injunctive norms.ConclusionsDescriptive and injunctive norms play roles in genomic sequencing decisions. Considering mediators and moderators of these processes enhances ability to optimize use of normative information to support informed decision making.