Cumulative conception and live birth rates in natural (unstimulated) IVF cycles
Cumulative conception and live birth rates in natural (unstimulated) IVF cycles
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DOI：
10.1093/humrep/16.2.259
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发表时间：
2001-02-01
影响因子：
6.1
通讯作者：
Campbell, S
中科院分区：
文献类型：
--
作者：
Nargund, G;Waterstone, J;Campbell, S
涉及卵巢刺激的IVF治疗会带来严重的健康问题，如卵巢过度刺激，并与多胎妊娠和早产的高发病率有关。在本文中，我们展示了自然周期IVF是如何成为某些不孕夫妇群体的有效和潜在成本效益的替代治疗选择。这项研究是在伦敦国王学院医学院的辅助受孕部门进行的。52名月经周期规律的女性，其伴侣精液参数正常，共接受了181个周期的治疗（平均每对夫妇3.49个周期）。生命表分析用于计算连续治疗周期后的累积成功率。四个周期后，累积妊娠概率为46%，相关活产率为32%。为了达到最大的效果，自然周期IVF应作为一系列治疗周期提供，因为它更安全、压力更小，并且可以在连续的周期中提供。此外，避免昂贵的药物和降低监测强度使自然周期IVF比涉及刺激的传统治疗更便宜。我们计算出，这种治疗可以提供类似的刺激周期的成本的23%，这表明它可能是一个具有成本效益的替代传统的辅助受孕技术。
IVF treatment, which involves ovarian stimulation, poses significant health problems such as ovarian hyperstimulation and is associated with a high incidence of multiple pregnancy and premature birth. In this paper, we demonstrate how natural cycle IVF is an effective and potentially cost-effective alternative treatment option for certain groups of infertile couples. The study was conducted in the Assisted Conception Unit at King's College School of Medicine, London. Fifty-two women with regular menstrual cycles whose partners had normal semen parameters were offered a total of 181 cycles of treatment (average 3.49 per couple). Life table analysis was used to calculate cumulative success rates after successive cycles of treatment. After four cycles, the cumulative probability of pregnancy was 46% with an associated live birth rate of 32%. To achieve maximal effectiveness, natural cycle IVF should be offered as a series of treatment cycles, for it is safer, less stressful and can be offered over consecutive cycles. Moreover, the avoidance of expensive drugs and reduced intensity of monitoring make natural cycle IVF less expensive than conventional treatment involving stimulation. We calculate that this treatment can be offered at similar to 23% of the cost of a stimulated cycle, suggesting that it may be a cost-effective alternative to conventional assisted conception techniques.