Regional assignment of genetic markers using a somatic cell hybrid panel: a WWW interactive program available for the pig genome

Regional assignment of genetic markers using a somatic cell hybrid panel: a WWW interactive program available for the pig genome
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DOI：
10.1093/bioinformatics/13.1.69
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发表时间：
1997-02
期刊：
Computer applications in the biosciences : CABIOS
影响因子：
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通讯作者：
C. Chevalet;J. Gouzy;Magali SanCristobal-Gaudy
C. Chevalet;J. Gouzy;Magali SanCristobal-Gaudy
中科院分区：
其他
文献类型：
--
作者：
C. Chevalet;J. Gouzy;Magali SanCristobal-Gaudy

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即使出现一些不一致的实验结果，通过使用一组具有细胞遗传学特征的体细胞杂种来快速简便地进行基因定位也是可能的。结果提出了一个交互式程序，并在WWW网站上提供给体细胞杂交面板的用户。基于似然计算和贝叶斯定理，对染色体和亚染色体区域进行分类，并提供置信水平。该方法在猪基因组的情况下说明。
MOTIVATION Quick and easy gene mapping by the use of a panel of cytogenetically characterized somatic cell hybrids is possible, even if some discordant experimental results arise. RESULTS An interactive program is proposed and is made available on a WWW site to users of a somatic cell hybrid panel. Assignments to chromosomes and subchromosomal regions are based on likelihood calculations and Bayes' theorem, and a confidence level is provided. The method is illustrated in the case of the pig genome.