PROGNOSTIC FACTORS AND PREDICTIVE SIGNS OF MALIGNANCY IN ADULT DERMATOMYOSITIS - A STUDY OF 32 CASES
PROGNOSTIC FACTORS AND PREDICTIVE SIGNS OF MALIGNANCY IN ADULT DERMATOMYOSITIS - A STUDY OF 32 CASES
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DOI：
10.1001/archderm.126.5.633
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发表时间：
1990-05-01
影响因子：
--
通讯作者：
TOURAINE, R
中科院分区：
文献类型：
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作者：
BASSETSEGUIN, N;ROUJEAU, JC;TOURAINE, R
皮肌炎(DM)是一种炎症性肌病，预后严重，主要由其与恶性肿瘤的相关性决定。我们介绍了一项对32名成年糖尿病患者的研究结果。我们的目标是定义癌症的预测迹象，并根据患者的生存情况建立预后因素。32例患者中13例(41%)合并糖尿病。经7年随访，总死亡率为52%。恶性肿瘤患者的死亡率更高。皮肤坏死和红细胞沉降率升高似乎是相关恶性肿瘤的潜在标志。发现了预后不良的典型迹象，如年龄和与癌症的关联。有趣的是，躯干广泛的皮肤损害和红细胞沉降率升高在死亡患者中也更常见。我们的结果表明，部分由皮肤体征定义的选定的DM患者组预后较差。
Dermatomyositis (DM) is an inflammatory myopathy with a severe prognosis mainly determined by its association with malignancy. We present the results of a study of 32 adults with DM. Our aim was to define predictive signs of cancer and establish prognostic factors according to patient survival. Thirteen (41%) of the 32 patients had DM associated with malignancy. After 7 years of follow-up, the overall mortality rate was 52%. Mortality was higher for patients with malignancy. Cutaneous necrosis and an elevated erythrocyte sedimentation rate appeared as potential markers of associated malignancy. Classic signs of poor prognosis, such as age and association with cancer were found. Interestingly, extensive cutaneous lesions on the trunk and an elevated erythrocyte sedimentation rate were also more frequent among the patients who died. Our results demonstrate that selected groups of patients with DM, in part defined by cutaneous signs, have a poor prognosis.