Hypertrophic remodeling: Gender differences in the early response to left ventricular pressure overload
Hypertrophic remodeling: Gender differences in the early response to left ventricular pressure overload
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DOI：
10.1016/s0735-1097(98)00347-7
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发表时间：
1998-10-01
影响因子：
24
通讯作者：
Lorell, BH
中科院分区：
文献类型：
--
作者：
Douglas, PS;Katz, SE;Lorell, BH
目标.研究大鼠升主动脉缩窄引起的压力超负荷对左心室重构、肥厚和功能的影响。性别可能会影响对压力负荷的适应，因为女性主动脉瓣狭窄患者的左心室肥厚程度更高，左心室功能更好。52只断奶大鼠接受升主动脉结扎术（16只雄性，18只雌性）或假手术（9只雄性，9只雌性）。在第6周和第20周，对大鼠进行经胸回波多普勒研究，并通过直接左心室穿刺闭合胸部左心室压力。对8只大鼠的灌注固定组织进行形态计量学检查，以测定肌细胞横截面积和胶原体积百分比。主动脉结扎后6周，雄性和雌性大鼠的左心室重塑、肥大程度和功能相似。在20周时，雄性而非雌性大鼠显示出早期向心力衰竭的转变，并出现腔扩张（左心室直径= 155%，同性为121%：假手术），向心性重塑丧失（相对壁厚= 102% vs. 139%假手术组），壁应力升高（收缩压= 266%对比假手术组的154%）和舒张功能障碍（快速充盈减速= 251%对比假手术组的190%）。与雄性大鼠相比，雌性大鼠的左心室收缩压较高（186 +/- 20 vs. 139 +/- 13 mm Hg），而舒张压往往较低（14 +/- 4 vs. 17 +/- 4 mm Bg）。性别显著影响压力超负荷早期反应的演变，包括主动脉瓣狭窄大鼠向心力衰竭的转变，（C）1998年美国心脏病学会。
Objectives. To identify gender differences in left ventricular remodeling, hypertrophy, and function in response to pressure overload due to ascending aortic banding in rats.Background. Gender may influence the adaptation to pressure overload, as women with aortic stenosis have greater degrees of left ventricular hypertrophy and better left ventricular function than men.Methods. Fifty-two,weanling rats underwent ascending aortic banding (16 males, 18 females), or sham surgery (9 males, 9 females). At 6 and 20 weeks, rats underwent transthoracic echo Doppler studies, and closed chest left ventricular pressures with direct left ventricular puncture. Perfusion-fixed tissues from eight rats were examined morphometrically for myocyte cross sectional area and percent collagen volume.Results. At 6 weeks after aortic banding, left ventricular remodeling, extent of hypertrophy, and function appeared similar in male and female rats. At 20 weeks, male but not female rats showed an early transition to heart failure, with onset of cavity dilatation (left ventricular diameter = 155% vs. 121% of same-sex: sham), loss of concentric remodeling (relative wall thickness = 102% vs. 139% of sham), elevated wall stress (systolic stress = 266% vs. 154% of sham), and diastolic dysfunction (deceleration of rapid filling = 251% vs. 190% of sham). Left ventricular systolic pressures were higher in female compared with male rats (186 +/- 20 vs. 139 +/- 13 mm Hg), while diastolic pressures tended to be lower (14 +/- 4 vs. 17 +/- 4 mm Bg).Conclusions. Gender significantly influences the evolution of the early response to pressure overload, including the transition to heart failure in rats with aortic stenosis, (C) 1998 by the American College of Cardiology.