Wet spun chitosan-collagen fibers, their chemical N-modifications, and blood compatibility
Wet spun chitosan-collagen fibers, their chemical N-modifications, and blood compatibility
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DOI：
10.1016/s0142-9612(99)00258-6
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发表时间：
2000-05-01
期刊：
影响因子：
14
通讯作者：
Miyata, T
中科院分区：
文献类型：
--
作者：
Hirano, S;Zhang, M;Miyata, T
在甲壳素与原胶原共混改善血液相容性的体外实验的基础上，我们制备了一种新型的生物相容性共混纤维及其N-化学修饰纤维。壳聚糖与原胶原或胶原蛋白的透明混合液(1g/30ml)和壳聚糖本身在2%醋酸-甲醇(2：1，v/v)水中的透明溶液在室温下通过粘胶型喷丝板纺丝到含有40-43%硫酸铵的5%氨水溶液中，得到白色的壳聚糖-原胶原蛋白共混物纤维(强度为1.08-1.65g/旦，伸长率为10.9-43.2%)。共混纤维中原胶原含量高达50%)对其强度和延伸值影响不大。用一系列羧酸酐和醛对共混纤维进行化学改性，得到相应的N改性纤维(强度为0.86~1.31g/旦，伸长率为8.0~12.1%)。将N-乙酰化壳聚糖(甲壳素)与原胶原蛋白共混制得透明共混水凝胶，并用该水凝胶制备了膜和海绵片。(C)2000爱思唯尔科学有限公司。保留所有权利。
Based on an in vitro test for an improvement of the blood compatibility of chitin by blending with tropocollagen, we prepared a novel biocompatible blended fiber and its chemically N-modified fibers. Each (1 g/30 ml) of a clear mixed solution of chitosan with tropocollagen or collagen and a clear solution of chitosan itself in aqueous 2% acetic acid-methanol (2 : 1, v/v) was spun through a viscose-type spinneret into an aqueous 5% ammonia solution containing 40-43% ammonium sulfate at room temperature to afford a white fiber of chitosan-tropocollagen blends (1.08-1.65 g/denier for the tenacity and 10.9-43.2% for the elongation). The tropocollagen content up to 50% by weight) in the blended fiber affected little their tenacity and elongation values. The blended fiber was chemically N-modified at the fiber state by treatment with a series of carboxylic anhydrides and aldehydes to afford the corresponding N-modified fiber (0.86-1.31 g/denier for the tenacity and 8.0-12.1% for the elongation). A transparent blended hydrogel of N-acetylchitosan (chitin) with tropocollagen was produced from the above mixed solution by treatment with acetic anhydride, and its membrane and sponge sheet were also prepared from the hydrogel. (C) 2000 Elsevier Science Ltd. All rights reserved.