SNP rs3825214 in TBX5 Is Associated with Lone Atrial Fibrillation in Chinese Han Population
SNP rs3825214 in TBX5 Is Associated with Lone Atrial Fibrillation in Chinese Han Population
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TBX5 中的 SNP rs3825214 与中国汉族人群中孤立性心房颤动相关
DOI：
10.1371/journal.pone.0064966
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发表时间：
2013-05
期刊：
影响因子：
3.7
通讯作者：
Tian, Xiaochen
中科院分区：
文献类型：
--
作者：
Wang, Qing;Zhang, Shulong;Xia, Yunlong;Li, Sisi;Fu, Fenfen;Li, Xiuchun;Wang, Fan;Zhang, Rongfeng;Tian, Xiaochen
背景PR间期延长是心律失常风险增加的标志。最近的全基因组关联研究发现，T-box 5（TBX 5）中的单核苷酸多态性（SNP）rs3825214与PR间期、QRS间期、QT间期以及常见心律失常疾病（如房颤（AF）和晚期房室传导阻滞）呈正相关。然而，需要其他独立的重复研究来验证结果。本研究评估了中国汉族人群rs3825214与ECG参数、AF和室性心动过速（VT）之间的相关性。为了评估rs3825214与AF和VT之间的关联，我们对692例AF患者（包括275例孤立性AF患者）、235例VT患者和856例对照进行了病例对照关联研究。使用Rotor-Gene TM 6000 High Resolution Melt系统进行基因分型。相关性的统计分析针对潜在的混杂因素进行了调整。在rs3825214和房颤之间检测到中度关联（P adj = 0.036，OR = 0.79），在rs3825214的G等位基因和孤立性房颤之间检测到高度显著关联（P adj = 0.001，OR = 0.65;基因型P = 3.75×10−4，显性模型）。 我们还发现rs3825214与房室传导阻滞显著相关（AVB; P = 0.028; P adj = 0.035，OR = 0.494）。 结论rs3825214在中国汉族人群中具有显著的孤立性房颤风险。
Background A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular block. However, other independent replication studies are required to validate the result. This study assessed associations between rs3825214 and ECG parameters, AF, and ventricular tachycardia (VT) in a Chinese Han population. Methodology/Principal Findings To assess the association between rs3825214 and AF and VT, we carried out case-control association studies with 692 AF patients (including 275 lone AF patients), 235 VT patients, and 856 controls. Genotyping was performed using a Rotor-Gene TM 6000 High Resolution Melt system. Statistical analyses of associations were adjusted for potential confounding factors. A moderate association was detected between rs3825214 and AF (P adj = 0.036, OR = 0.79) and a highly significant association was detected between the G allele of rs3825214 and lone AF (P adj = 0.001, OR = 0.65; genotypic P = 3.75×10−4 with a dominant model). We also found that rs3825214 showed a significant association with atrial-ventricular block (AVB; P = 0.028; P adj = 0.035, OR = 0.494). Conclusions Our results indicate that rs3825214 conferred a significant risk of lone AF in this Chinese Han population.
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影响因子：
2.3
作者：
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通讯作者：
Knollmann BC
DOI：
10.1016/s0197-2456(98)00037-3
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期刊：
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影响因子：
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作者：
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