Multifocal histoplasmosis due to Histoplasma capsulatum var. duboisii in a 22 year-old Senegalese patient without proven immunodepression
Multifocal histoplasmosis due to Histoplasma capsulatum var. duboisii in a 22 year-old Senegalese patient without proven immunodepression
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DOI：
10.1016/j.mycmed.2016.03.004
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发表时间：
2016-09-01
影响因子：
3.6
通讯作者：
Dieng, M. T.
中科院分区：
文献类型：
--
作者：
Diadie, S.;Diatta, B.;Dieng, M. T.
作者报告了一例多灶性非洲组织胞浆菌病，患者多形性皮肤受累，且未经过证实的免疫抑制治疗。他是一名来自塞内加尔东部但出生于乌干达的 22 岁年轻患者，出现多形性皮肤病变：环状丘疹结节、牙龈以及溃疡性和出芽性病变。他表现出淋巴结病，但没有临床炎症，活检组织外观呈干酪状，但没有结核病，也没有肝脾和骨骼受累。皮肤真菌学样本和淋巴结活检显示存在荚膜组织胞浆菌变种酵母。 duboisii 在 Sabouraud 培养基上具有阳性培养物。 HIV血清学、HTLV1et 2、血清蛋白电泳未见异常。由于在国内难以获得且费用昂贵，两性霉素 B 的治疗不规范。患者因败血症并病情加重而死亡。 (C) 2016 Elsevier Masson SAS。版权所有。
The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal but born in Ouganda who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulcerative and budding lesions. He showed lymphadenopathies without clinical inflammation and with a cheesy appearance of the biopsy but without tuberculosis and also hepatosplenic and bone involvement. Mycological samples of the skin and lymph nodes biopsies revealed yeasts of Histoplasma capsulatum var. duboisii with a positive culture on Sabouraud medium. HIV serology, HTLV1et 2, the serum proteins electrophoresis were unremarkable. Treatment with amphotericin B was irregular because of its inaccessibility in the national territory and its cost. The patient died of sepsis together with the aggravation of his disease. (C) 2016 Elsevier Masson SAS. All rights reserved.