The minimal behavioral time window for reward conditioning in the nucleus accumbens of mice
The minimal behavioral time window for reward conditioning in the nucleus accumbens of mice
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小鼠伏隔核奖赏调节的最小行为时间窗
DOI：
10.1101/641365
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yagishita Sho
中科院分区：
文献类型：
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作者：
Yamaguchi Kenji;Maeda Yoshitomo;Sawada Takeshi;Iino Yusuke;Tajiri Mio;Nakazato Ryosuke;Kasai Haruo;Yagishita Sho
奖励强化学习的时间精度由奖励行动的最小时间窗口决定——理论上称为资格轨迹。然而，在动物研究中，这样一个最短的时间窗口及其起源尚未得到很好的理解。在这里，我们使用头部受限的小鼠来精确控制蔗糖水作为无条件刺激的时间（美国）；我们发现US的强化效应仅在条件刺激（CS）的短音后1秒内发生。这种调节需要伏隔核 (NAc) 中的多巴胺 D1 受体和 CaMKII 信号传导。用 NAc 突触输入的光遗传学刺激取代 CS 并没有减少时间窗口，这与之前关于 NAc 突触有效多巴胺时间的报道一致。因此，我们的数据表明最小奖励时间窗口是 1 s，并且是在 NAc 中形成的。
The temporal precision of reward-reinforcement learning is determined by the minimal time window of the reward action—theoretically known as the eligibility trace. In animal studies, however, such a minimal time window and its origin have not been well understood. Here, we used head-restrained mice to accurately control the timing of sucrose water as an unconditioned stimulus (US); we found that the reinforcement effect of the US occurred only within 1 s after a short tone of a conditioned stimulus (CS). The conditioning required the dopamine D1 receptor and CaMKII signaling in the nucleus accumbens (NAc). The time window was not reduced by replacing CS with optogenetic stimulation of the synaptic inputs to the NAc, which is in agreement with previous reports on the effective dopamine timing of NAc synapses. Thus, our data suggest that the minimal reward time window is 1 s, and is formed in the NAc.