Phylogenetic analysis of GBV-C/hepatitis G virus
Phylogenetic analysis of GBV-C/hepatitis G virus
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DOI：
10.1099/0022-1317-81-3-769
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发表时间：
2000-03-01
影响因子：
3.8
通讯作者：
Simmonds, P
中科院分区：
文献类型：
--
作者：
Smith, DB;Basaras, M;Simmonds, P
对 33 种流行病学上不同的 GBV-C/G 型肝炎病毒完整基因组序列的比较表明，存在四个主要系统发育分组，它们与黑猩猩分离株 GBV-C-tro 同样不同，并且具有不同的地理分布。通过对病毒 5'-非编码区 (5'-NCR) 或单个基因或亚基因组片段的分析，这四个分组并不能一致地重现，但 E2 基因整体或3' 半部分有 200-600 个核苷酸片段。该区域位于所提出的反义阅读框的上游，包含保守的潜在 RNA 二级结构，可能能够指导内部翻译起始。对来自某些南非分离株的该区域的系统发育分析与之前对 5'-NCR 的分析一致，表明这些分离株属于第五组。病毒变种的地理分布与漫长的进化历史一致，可能与史前人类迁徙平行，这意味着这种RNA病毒的长期进化极其缓慢。
Comparison of 33 epidemiologically distinct GBV-C/hepatitis G virus complete genome sequences suggests the existence of four major phylogenetic groupings that are equally divergent from the chimpanzee isolate GBV-C-tro and have distinct geographical distributions, These four groupings are not consistently reproduced by analysis of the virus 5'-noncoding region (5'-NCR), or of individual genes or subgenomic fragments with the exception of the E2 gene as a whole or of 200-600 nucleotide fragments from its 3' half. This region is upstream of a proposed anti-sense reading frame and contains conserved potential RNA secondary structures that may be capable of directing the internal initiation of translation. Phylogenetic analysis of this region from certain South African isolates is consistent with previous analysis of the 5'-NCR suggesting that these belong to a fifth group. The geographical distribution of virus variants is consistent with a long evolutionary history that may parallel that of pre-historic human migrations, implying that the long-term evolution of this RNA virus is extremely slow.