IMAGING OF PRIMARY AND METASTATIC COLORECTAL-CANCER USING AN IN-111-LABELLED ANTITUMOUR MONOCLONAL-ANTIBODY (791T/36)
IMAGING OF PRIMARY AND METASTATIC COLORECTAL-CANCER USING AN IN-111-LABELLED ANTITUMOUR MONOCLONAL-ANTIBODY (791T/36)
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DOI：
10.1097/00006231-198510000-00003
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发表时间：
1985-01-01
影响因子：
1.5
通讯作者：
HARDCASTLE, JD
中科院分区：
文献类型：
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作者：
ARMITAGE, NC;PERKINS, AC;HARDCASTLE, JD
单克隆抗肿瘤抗体 791T/36 先前显示用 131 I 放射性标记时可定位于结直肠癌，现已成功用 111 In 标记。已在 14 名原发性和继发性结直肠癌患者中对其成像潜力进行了初步评估。除一名患者外，所有患者的肿瘤部位均实现了阳性定位。与使用 131 I 标记的相同抗体相比， 111 In 标记抗体的摄取位点更清晰。来自四个切除标本的每克组织的平均肿瘤与正常组织摄取比率为 2.8:1。
The monoclonal antitumour antibody 791T/36, previously shown to localize in colorectal cancer when radiolabelled with 131 I, has been successfully labelled with 111 In. A preliminary evaluation of its imaging potential has been made in fourteen patients with primary and secondary colorectal cancer. Positive localization was achieved in tumour sites of all but one of the patients. The sites of uptake of the 111 In-labelled antibody were more clearly defined than when using the same antibody labelled with 131 I. The mean tumour to normal tissue uptake ratio per gram of tissue from four resected specimens was 2.8: 1.