Deciphering treatment resistance in metastatic colorectal cancer: roles of drug transports, EGFR mutations, and HGF/c-MET signaling.
Deciphering treatment resistance in metastatic colorectal cancer: roles of drug transports, EGFR mutations, and HGF/c-MET signaling.
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转移性结直肠癌的解密治疗耐药性：药物转运，EGFR突变和HGF/C-MET信号传导的作用。
DOI：
10.3389/fphar.2023.1340401
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
到2023年，结直肠癌（CRC）是全球第三大确诊恶性肿瘤和第三大癌症死亡原因。在初次就诊时，20%诊断为CRC的患者患有转移性CRC（mCRC），另外25%的局部疾病患者随后会发生转移。尽管各种调节策略（如化疗联合靶向治疗、放疗和免疫治疗）的缓解率有所改善，但mCRC的预后较差，5年生存率为14%，治疗失败的主要原因被认为是对治疗产生耐药性。本文综述了mCRC耐药的主要机制，特别强调了药物转运、EGFR和HGF/c-MET信号通路在介导mCRC耐药中的作用，并讨论了最近逆转药物转运引起的耐药和EGFR突变引起的抗EGFR阻断剂耐药以及HGF/c-MET信号通路改变的治疗方法。
In 2023, colorectal cancer (CRC) is the third most diagnosed malignancy and the third leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients diagnosed with CRC have metastatic CRC (mCRC), and another 25% who present with localized disease will later develop metastases. Despite the improvement in response rates with various modulation strategies such as chemotherapy combined with targeted therapy, radiotherapy, and immunotherapy, the prognosis of mCRC is poor, with a 5-year survival rate of 14%, and the primary reason for treatment failure is believed to be the development of resistance to therapies. Herein, we provide an overview of the main mechanisms of resistance in mCRC and specifically highlight the role of drug transports, EGFR, and HGF/c-MET signaling pathway in mediating mCRC resistance, as well as discuss recent therapeutic approaches to reverse resistance caused by drug transports and resistance to anti-EGFR blockade caused by mutations in EGFR and alteration in HGF/c-MET signaling pathway.
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影响因子：
4.7
作者：
Gao HL;Gupta P;Cui Q;Ashar YV;Wu ZX;Zeng L;Lei ZN;Teng QX;Ashby CR Jr;Guan Y;Chen ZS
通讯作者：
Chen ZS
影响因子：
--
作者：
Wang XK;To KK;Huang LY;Xu JH;Yang K;Wang F;Huang ZC;Ye S;Fu LW
通讯作者：
Fu LW
影响因子：
28.2
作者：
Bardelli A;Corso S;Bertotti A;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S
通讯作者：
Siena S
影响因子：
11.5
作者：
Boyer, J;McLean, EG;Johnston, PG
通讯作者：
Johnston, PG
影响因子：
4.2
作者：
Barlaam, Bernard;Anderton, Judith;Ogilvie, Donald
通讯作者：
Ogilvie, Donald