Enhancing the Working Memory of Stroke Patients Using tDCS
Enhancing the Working Memory of Stroke Patients Using tDCS
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DOI：
10.1097/phm.0b013e3181a0e4cb
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发表时间：
2009-05-01
影响因子：
3
通讯作者：
Lee, Kwang Ho
中科院分区：
文献类型：
--
作者：
Jo, Jung Mi;Kim, Yun-Hee;Lee, Kwang Ho
目的：我们调查是否阳极经颅直流电刺激左背外侧前额叶皮质影响工作记忆性能的患者after a stroke.Design：10例（平均年龄47.7岁）首次中风后的认知缺陷参加了这个单盲，交叉，和假对照实验。每例患者被随机分配接受两次经颅直流电刺激：阳极背外侧前额叶皮层和假刺激48小时内的洗脱期。所有参与者在经颅直流电刺激之前和之后进行了双背工作记忆任务。准确性（纠正率），识别准确性（纠正率，委员会错误率），并在每个experiments.Results：重复测量方差分析表明，经颅直流电刺激类型和时间上的识别准确性显着的相互作用。事后分析显示，在阳极刺激组，但不是在假刺激组的刺激前和刺激后的显着差异。关于准确性，配对t检验表明只有在阳极经颅直流电刺激后才有显著改善，两种经颅直流电刺激类型之间没有显著的相互作用。在阳极和假刺激groups.Conclusion的反应时间没有显着差异：我们的研究结果表明，阳极经颅直流电刺激左背外侧前额叶皮层与增强的工作记忆表现为索引的识别准确性中风后的患者。
Objectives: We investigated whether anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex affected the working memory performance of patients after a stroke.Design: Ten patients (mean age 47.7 yrs) with cognitive deficits after a first-ever stroke participated in this single-blind, crossover, and sham-controlled experiment. Each patient was randomly assigned to undergo two transcranial direct current stimulation sessions: anodal dorsolateral prefrontal cortex and sham stimulation within 48 hrs of a washout period. All participants performed a two-back working memory task before and after the administration of the transcranial direct current stimulation. Accuracy (correction rate), recognition accuracy (correction rate-commission error rate), and response time were measured during each experiment.Results: Repeated-measures analysis of variance indicated a significant interaction effect of transcranial direct current stimulation type and time on the recognition accuracy. Post hoc analyses revealed a significant difference between prestimulation and poststimulation in the anodal stimulation group but not in the sham stimulation group. Regarding the accuracy, the paired t test indicated significant improvement only after anodal transcranial direct current stimulation without a significant interaction effect between the two transcranial direct current stimulation types. The response time was not significantly different in the anodal and sham stimulation groups.Conclusion: Our results demonstrated that anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex was associated with enhanced working memory performance as indexed by the recognition accuracy in patients after a stroke.