Age and education correction of mini-mental state examination for English and Spanish-speaking elderly
Age and education correction of mini-mental state examination for English and Spanish-speaking elderly
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DOI：
10.1212/wnl.46.3.700
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发表时间：
1996-03-01
期刊：
影响因子：
9.9
通讯作者：
Reed, BR
中科院分区：
文献类型：
--
作者：
Mungas, D;Marshall, SC;Reed, BR
先前的研究表明，简易精神状态检查表（MMS）在作为少数族裔和低教育程度患者认知障碍的衡量指标时存在偏差。本研究的目的是：（1）针对年龄和教育的影响制定一种统计校正方法；（2）使用不同的种族群体和教育水平，测试经统计调整后的MMS（MMSAdj）作为痴呆筛查测试的有效性。我们使用了一个基于人群的社区调查样本（n = 590），其中包括46.6%的西班牙裔和53.4%的非西班牙裔，以得出统计校正公式，定义为：MMSAdj = 原始MMS -（0.471×[教育程度 - 12]）+（0.131×[年龄 - 70]）。在社区调查样本中，种族和测试所使用的语言与MMSAdj并无显著关联，但原始MMS却受到这些因素的强烈影响。我们使用了一个独立样本（n = 2983），这些患者是通过加利福尼亚州阿尔茨海默病诊断和治疗中心进行评估的，以测试MMS和MMSAdj在低教育程度和高教育程度群体以及白人、西班牙裔和黑人中的诊断准确性。结果显示，与原始MMS相比，MMSAdj在不同教育水平和种族群体中的敏感性和特异性具有更高的稳定性，这表明对于低教育程度和少数族裔个体而言，MMSAdj是一种更优的认知障碍衡量指标。
Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. The purpose of this study was to (1) develop a statistical correction for effects of age and education and (2) test the efficacy of the statistically adjusted MMS (MMSAdj) as a screening test for dementia using different ethnic groups and education levels, We used a population-based community survey sample (n = 590) composed of 46.6% Hispanics and 53.4% non-Hispanics to derive the statistical correction, defined as: MMSAdj = Raw MMS - (0.471 x [Education-12]) + (0.131 x [Age-70]). Ethnicity and language of test administration were not significantly related to MMSAdj in the community survey sample, but the raw MMS was strongly influenced by these factors. We used an independent sample (n = 2,983) of patients evaluated through the California Alzheimer's Disease Diagnostic and Treatment Centers to test the diagnostic accuracy of the MMS and the MMSAdj across low- and high-education groups and across whites, Hispanics, and blacks. Results showed greater stability of sensitivity and specificity across education levels and ethnic groups for the MMSAdj than for the raw MMS and suggest that the MMSAdj is a preferable measure of cognitive impairment for low-education and minority individuals.