REWARD AND REINFORCEMENT PRODUCED BY DRINKING SUCROSE - 2 PROCESSES THAT MAY DEPEND ON DIFFERENT NEUROTRANSMITTERS
REWARD AND REINFORCEMENT PRODUCED BY DRINKING SUCROSE - 2 PROCESSES THAT MAY DEPEND ON DIFFERENT NEUROTRANSMITTERS
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DOI：
10.1016/0091-3057(95)00128-j
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发表时间：
1995-10-01
影响因子：
3.6
通讯作者：
TALAMANTES, B
中科院分区：
文献类型：
--
作者：
AGMO, A;GALVAN, A;TALAMANTES, B
研究了蔗糖饮用产生条件位置偏好（CPP）的能力，以及多巴胺和阿片受体阻断对这种偏好的获得和蔗糖消耗的影响。地点偏好的建立反映了饮酒的强化后果，而蔗糖溶液的消耗量则说明了其奖励特性。雄性Wistar大鼠被允许饮用18%的蔗糖溶液。没有使用剥夺。饮酒会产生位置偏好，这种偏好被顺式氟哌噻醇0.5 mg/kg阻断。纳洛酮16 mg/kg不仅阻断了部位偏好，而且减少了蔗糖的消耗。事实上，这些动物摄入的水和老鼠摄入白开水的量差不多。较低剂量的纳洛酮（1和4 mg/kg）也减少了蔗糖的消耗，但1 mg/kg没有阻止部位偏好。由于多巴胺拮抗剂在抑制条件位置偏好的剂量下不影响摄入，这表明多巴胺对蔗糖产生的强化的建立至关重要。阿片类药物似乎对奖励效果更重要，因为纳洛酮即使在不影响地点偏好的剂量下也能减少饮酒。
The capacity of sucrose drinking to produce conditioned place preference (CPP) and the effects of dopamine and opioid receptor blockade on acquisition of this preference and on sucrose consumption were evaluated. The establishment of place preference would reflect the reinforcing consequences of drinking, while the amount of sucrose solution consumed would illustrate its rewarding properties. Male Wistar rats were allowed to drink an 18% sucrose solution. No deprivation was used. Drinking produced place preference, and this was blocked with cis(z)-flupentixol, 0.5 mg/kg. Naloxone, 16 mg/kg, not only blocked place preference, but also reduced sucrose consumption. In fact, animals consumed amounts similar to those consumed by rats given plain water. Lower doses of naloxone, 1 and 4 mg/kg, also decreased sucrose consumption, but 1 mg/kg did not block place preference. As the dopamine antagonist did not affect consumption at a dose that inhibited conditioned place preference, it is suggested that dopamine is critical for the establishment of reinforcement produced by sucrose. Opioids seem to be more important for the rewarding effect because naloxone reduces drinking even at a dose that does not affect place preference.