ON THE FACTORS WHICH CONTRIBUTE TO THINNING OF THE VILLOUS MEMBRANE IN HUMAN PLACENTAE AT HIGH-ALTITUDE .1. THINNING AND REGIONAL VARIATION IN THICKNESS OF TROPHOBLAST
ON THE FACTORS WHICH CONTRIBUTE TO THINNING OF THE VILLOUS MEMBRANE IN HUMAN PLACENTAE AT HIGH-ALTITUDE .1. THINNING AND REGIONAL VARIATION IN THICKNESS OF TROPHOBLAST
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DOI：
10.1016/0143-4004(88)90067-7
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发表时间：
1988-01-01
期刊：
影响因子：
3.8
通讯作者：
HAAS, JD
中科院分区：
文献类型：
--
作者：
JACKSON, MR;MAYHEW, TM;HAAS, JD
采用体视学方法分析了玻利维亚土著和非土著人群在低海拔和高海拔分娩的人类足月胎盘切片。估计绒毛膜和滋养层的算术和调和平均厚度。然后用这些值来推导厚度变化指数。没有显着的种族，性别或相互作用的影响被发现。在高海拔地区，绒毛膜的厚度明显更易变，由于较低的谐波平均值，但相同的算术平均厚度。滋养层的算术平均厚度和调和平均厚度的改变导致绒毛膜变薄。高海拔地区滋养细胞较薄，厚度不规则。这些发现的背景下，胎盘弥散能力和血管合胞膜形成的可能机制进行了讨论。
Sections of human term placentae delivered at low and high altitude to indigenous and nonindigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indices of thickness variation. No significant ethnic, sex or interaction effects were found. At high altitude, the villous membrane was significantly more variable in thickness owing to a lower harmonic mean but the same arithmetic mean thickness. Alterations in the arithmetic and harmonic mean thicknesses of the trophoblast contributed to the thinning of the villous membrane. The trophoblast was thinner and more irregular in thickness at high altitude. These findings are discussed in the context of placental diffusing capacity and the possible mechanisms for formation of vasculosyncytial membranes.