Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder
Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder
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DOI：
10.1002/da.22606
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发表时间：
2017-05-01
影响因子：
7.4
通讯作者：
Farmer, Anne E.
中科院分区：
文献类型：
--
作者：
Hosang, Georgina M.;Fisher, Helen L.;Farmer, Anne E.
背景一小部分研究表明，基因-环境相互作用在双相情感障碍的发展中起着重要作用。本研究的目的是有助于这项工作，通过探索紧张的生活事件和儿茶酚-O-甲基-转移酶（COMT）瓦尔（158）Met多态性在双相障碍. MethodsFour-Eighth-Two-bipolar的情况下，205精神健康对照完成了威胁的经验问卷列表之间的关系。双相情感障碍病例报告了在最严重的抑郁和躁狂发作前6个月发生的事件;对照组报告了在访谈前6个月发生的事件。COMT瓦尔（158）Met变异体（rs 4680）的基因型信息提取GWAS分析的sample.ResultsThe的影响是缓和的COMT基因型最严重的抑郁发作使用瓦尔显性模型（调整后的风险差= 0.09，95%置信区间= 0.003-0.18，P = 0.04）。对于最严重的躁狂发作没有显着的COMT和紧张的生活事件之间的相互作用determined.ConclusionsThis是第一个研究探讨紧张的生活事件和COMT瓦尔（158）Met多态性之间的关系专注于双相情感障碍。这项研究的结果突出了遗传和环境因素之间的相互作用对双相抑郁症的重要性。
BackgroundA small body of research suggests that gene-environment interactions play an important role in the development of bipolar disorder. The aim of the present study is to contribute to this work by exploring the relationship between stressful life events and the catechol-O-methyl-transferase (COMT) Val(158)Met polymorphism in bipolar disorder.MethodsFour hundred eighty-two bipolar cases and 205 psychiatrically healthy controls completed the List of Threatening Experiences Questionnaire. Bipolar cases reported the events experienced 6 months before their worst depressive and manic episodes; controls reported those events experienced 6 months prior to their interview. The genotypic information for the COMT Val(158)Met variant (rs4680) was extracted from GWAS analysis of the sample.ResultsThe impact of stressful life events was moderated by the COMT genotype for the worst depressive episode using a Val dominant model (adjusted risk difference = 0.09, 95% confidence intervals = 0.003-0.18, P = .04). For the worst manic episodes no significant interactions between COMT and stressful life events were detected.ConclusionsThis is the first study to explore the relationship between stressful life events and the COMT Val(158)Met polymorphism focusing solely on bipolar disorder. The results of this study highlight the importance of the interplay between genetic and environmental factors for bipolar depression.