Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels
Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels
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DOI：
10.1097/tp.0b013e3181837626
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发表时间：
2008-09-15
期刊：
影响因子：
6.2
通讯作者：
Stegall, Mark D.
中科院分区：
文献类型：
--
作者：
Issa, Naim;Cosio, Fernando G.;Stegall, Mark D.
背景移植肾小球病（TG）是一种与抗人类白细胞抗原（HLA）抗体相关的同种异体肾移植的组织病理学实体。本研究的目的是确定抗体特征（水平和特异性）、TG风险和移植物存活率之间的关系。采用单抗原微珠法检测了598例T细胞交叉配型阴性肾移植受者移植前血清中抗HLA抗体的存在和特点。通过监测和临床活检诊断移植物肾病。39%的患者在移植前出现抗HLA抗体。在54 +/- 19个月的随访中，73例患者（12%）诊断为移植肾小球病。抗HLA-II抗体水平越高，发生TG的危险性越大（HR = 1.890，95%CI 1.42-2.52; P
Background. Transplant glomerulopathy (TG) is a histopathologic entity of kidney allografts related to anti-human leukocyte antigen (HLA) antibodies. The goal of this study was to determine the relationships among antibody characteristics (level and specificity), risk for TG, and graft survival.Methods. The presence and characteristics of anti-HLA antibody were assessed by single antigen beads assays in stored pretransplant sera from 598 kidney recipients with negative T-cell crossmatch. Transplant glomerulopathy was diagnosed by surveillance and clinical biopsies.Results. Thirty-nine percent of patients presented with anti-HLA antibodies pretransplant. Transplant glomerulopathy was diagnosed in 73 patients (12%) during 54 +/- 19 months of follow-up. The risk of TG increased with higher anti-HLA-II antibody levels (HR = 1.890, 95% CI 1.42-2.52; P