Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis
Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis
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DOI：
10.2174/09298673113209990036
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发表时间：
2013-09-01
影响因子：
4.1
通讯作者：
Yuk, Soon Hong
中科院分区：
文献类型：
--
作者：
Jung, Yong Woo;Lee, Hwanbum;Yuk, Soon Hong
基于Pluronic的核/壳纳米粒子（NPs）使用各种策略形成，例如自组装和温度诱导相变。为了提高它们作为诊断和治疗的纳米药物的功能，采用囊泡融合和逐层方法。由于Pluronic壳的亲水性和相对小的尺寸，使用基于Pluronic的核/壳NP以改善其在药物和成像剂中的药代动力学行为。本文将介绍各种类型的基于Pluronic的核/壳纳米粒子的制备方法和形成机制。重点将放在基于Pluronic的核/壳纳米粒子上，用于肿瘤靶向，刺激蛋白质释放和癌症成像能力。
Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.