Phospholipid/zein hybrid nanoparticles as promising carriers for the protection and delivery of all-trans retinoic acid
Phospholipid/zein hybrid nanoparticles as promising carriers for the protection and delivery of all-trans retinoic acid
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DOI：
10.1016/j.msec.2021.112331
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发表时间：
2021-07-24
影响因子：
7.9
通讯作者：
Cosco, Donato
中科院分区：
文献类型：
--
作者：
Gagliardi, Agnese;Voci, Silvia;Cosco, Donato
为了有效提高全反式维甲酸（ATRA）的光稳定性，同时保持其药理学特性，开发了一种由磷脂和玉米醇溶蛋白组成的可完全生物降解的混合体系。光子相关光谱显示，使用磷脂85 G和玉米醇溶蛋白以7：3 w/w的比例获得的制剂的特征在于小于200 nm的平均直径、窄的尺寸分布和显著的时间和温度依赖性稳定性。使用特定的冷冻保护剂，如甘露糖和葡萄糖有利于长期储存的纳米载体后的冷冻干燥程序。纳米颗粒增加了ATRA对光化学降解的稳定性，相对于游离药物，其抗肿瘤作用被保留作为胶体系统的细胞摄取的结果。结果表明，所提出的混合纳米系统的潜力，提供了一个高水平的稳定敏感和不稳定的抗肿瘤化合物。
A totally biodegradable mixed system made up of phospholipids and zein was developed in order to effectively improve the photostability of all-trans retinoic acid (ATRA) preserving its pharmacological properties. Photon correlation spectroscopy showed that the formulation obtained using phospholipon 85G and zein at a ratio of 7:3 w/w was characterized by an average diameter of less than 200 nm, a narrow size distribution and a significant time- and temperature-dependent stability. The use of specific cryoprotectants such as mannose and glucose favoured the long-term storage of the nanocarriers after the freeze-drying procedure. The nanoparticles increased the stability of the ATRA against photochemical degradation with respect to the free drug and its antitumor effect was preserved as a consequence of the cell uptake of the colloidal systems. The results demonstrate the potential of the proposed hybrid nanosystems to provide a high level of stabilization for sensitive and labile antitumor compounds.