METRONIDAZOLE IS BACTERICIDAL TO DORMANT CELLS OF MYCOBACTERIUM-TUBERCULOSIS
METRONIDAZOLE IS BACTERICIDAL TO DORMANT CELLS OF MYCOBACTERIUM-TUBERCULOSIS
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DOI：
10.1128/aac.38.9.2054
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发表时间：
1994-09-01
影响因子：
4.9
通讯作者：
SRAMEK, HA
中科院分区：
文献类型：
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作者：
WAYNE, LG;SRAMEK, HA
非常突然地暴露在厌氧条件下，对活跃生长的结核分枝杆菌培养物具有致命影响。然而，在氧气耗尽的条件下孵育会逐渐导致结核分枝杆菌从活跃的复制转变为休眠。休眠的细菌对厌氧菌的杀菌作用具有抵抗力，对异烟肼和利福平的杀菌作用也表现出部分或完全的抗药性。另一方面，甲硝唑是一种专门针对厌氧菌的药物，在厌氧条件下可以杀死休眠的结核杆菌，但对活跃生长的有氧培养物没有影响。甲硝唑在厌氧条件下的致死作用被利福平增强。讨论了这些发现对结核病潜伏期现象的可能影响。
Very abrupt exposure to anaerobic conditions has a lethal effect on actively growing cultures of Mycobacterium tuberculosis. However, incubation under conditions in which oxygen is depleted gradually causes M. tuberculosis to shift down from active replication to dormancy. The dormant bacilli are resistant to the bactericidal effects of anaerobiosis and also exhibit partial or complete resistance to the bactericidal effects of isoniazid and rifampin. On the other hand, metronidazole, a drug specific for anaerobes, kills dormant tubercle bacilli under anaerobic conditions, but it has no effect on actively growing aerobic cultures. The lethal effect of metronidazole under anaerobic conditions is enhanced by rifampin. The possible implications of these findings on the phenomenon of latency in tuberculosis are discussed.