Malignant pericardial mesothelioma. Report of two cases, review of the literature and differential diagnosis
Malignant pericardial mesothelioma. Report of two cases, review of the literature and differential diagnosis
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DOI：
10.1177/030089160509100315
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发表时间：
2005-05-01
期刊：
影响因子：
--
通讯作者：
Ravaioli, A
中科院分区：
文献类型：
--
作者：
Papi, M;Genestreti, G;Ravaioli, A
恶性心包间皮瘤是一种罕见的原发恶性心包肿瘤，是一种高致命性且罕见的心脏肿瘤。心包间皮瘤的临床表现无特异性，病理上心包间皮瘤在心包原发肿瘤中并不常见。它的特点是间皮细胞不典型的固体生长，形成不典型的空洞，周围有纤维基质。生前诊断困难，远处转移极为罕见。根治性手术可用于治疗局限性间皮瘤。晚期原发性心包间皮瘤的治疗通常是姑息性的，因为肿瘤对放疗和化疗具有抵抗力。预后不良。出现症状后的中位生存期为6个月。本文报告两例无明确石棉接触史的原发性心包间皮瘤患者。
Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac neoplasm. The presentation of pericardial mesothelioma is aspecific and pathologically mesothelioma is not the most common among primary tumors of the pericardium. It is characterized by atypical solid growth of mesothelium with formation of atypical cavities surrounded by fibrous stroma. Antemortem diagnosis is difficult and distant metastases are extremely rare. Radical surgery can be used to treat localized mesothelioma. The treatment for advanced primary pericardial mesothelioma is usually palliative because the tumor is resistant to radiotherapy and chemotherapy. The prognosis is unfavorable. The median survival from the onset of symptoms is six months. In this paper we report two cases of patients with primary mesothelioma of the pericardium without a definite history of asbestos exposure.