Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study
Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study
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DOI：
10.1038/s41598-024-53929-w
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发表时间：
2024-02-13
影响因子：
4.6
通讯作者：
Ertaylan，Goekhan
中科院分区：
文献类型：
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作者：
Delanote，Julie;Correa Rojo，Alejandro;Ertaylan，Goekhan
精神障碍是受多种遗传、环境和生物因素影响的复杂疾病。特定的微生物群失衡似乎会影响心理健康状况。然而，微生物群失调影响抑郁、压力、焦虑和饮食失调的机制仍然知之甚少。目前，还没有确定可靠的生物标志物。我们提出了一种新的双层设计，以准确地识别微生物/代谢组学签名的基础上的精神疾病在TwinsUK注册。单卵双胞胎和双卵双胞胎不一致的精神障碍进行了筛选，在成对的方式，差异丰富的细菌属和循环代谢产物。此外，还进行了多变量分析，考虑了个体水平的混杂因素。我们的多层研究设计使我们能够克服具有显著混杂效应的横断面研究设计的局限性，并导致副杆菌属的丰度与精神障碍的诊断相关。未来的研究应该探索副杆菌作为心理健康状况的中介的潜在作用。我们的研究结果表明，微生物组作为精神疾病修饰剂的潜在作用可能有助于开发评估个人风险和干预策略的新方法。
Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genusParabacteroideswith the diagnosis of mental disorders. Future research should explore the potential role ofParabacteroidesas a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies.