Cohort Profile: The 1969-73 Vellore birth cohort study in South India
Cohort Profile: The 1969-73 Vellore birth cohort study in South India
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DOI：
10.1093/ije/dyn159
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发表时间：
2009-06-01
影响因子：
7.7
通讯作者：
Fall, Caroline H. D.
中科院分区：
文献类型：
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作者：
Antonisamy, B.;Raghupathy, P.;Fall, Caroline H. D.
高生育率和婴儿死亡率几十年来一直是印度的特点。需要对怀孕率进行系统研究，并对婴儿进行纵向观察，以评估这些问题的严重程度，评价因果因素，并确定死亡风险高的婴儿。印度缺乏这种纵向研究。因此，在1969年至1973年，来自韦洛雷基督教医学院的Rao教授和Inbaraj建立了一项关于孕产妇健康和妊娠结局的纵向研究。1-5它包括生活在北阿尔科特区特定城市和农村地区的母亲。除了出生时的测量外，婴儿在婴儿期还接受了各种结果的随访。随后，对6-8岁和10-15岁的儿童进行随访，以研究产前因素对儿童和青少年时期身体生长，发育和健康的影响。根据一些将产前因素和儿童生长与成人慢性疾病（如2型糖尿病（DM）和冠心病）联系起来的研究的出版物，6-11决定重新追踪1998-2002年的队列，然后年龄为26-32岁，以研究母体大小的关系，新生儿的大小和儿童生长轨迹与这些年轻的南印度成年人的心血管疾病风险因素有关。
High fertility and infant mortality rates have been features of India for several decades. A systematic study of the incidence of pregnancy and longitudinal observation of the babies was required to assess the scale of these problems, evaluate the causal factors and identify babies at high risk of mortality. Such longitudinal studies were lacking in India. Thus, in 1969–73, Professor Rao and Inbaraj from the Christian Medical College, Vellore established a longitudinal study of maternal health and pregnancy outcomes. 1–5 It included mothers living within specified urban and rural areas of the North Arcot district. Besides measurements at birth, the babies were followed up during infancy for a variety of outcomes. Subsequently, the children were followed up between the ages of 6–8 years, and 10–15 years to study the effects of prenatal factors on physical growth, development and health during childhood and adolescence. Following publications from a number of studies linking prenatal factors and childhood growth to adult chronic diseases such as Type 2 diabetes mellitus (DM) and coronary heart disease, 6–11 it was decided to re-trace the cohort in 1998–2002, then aged 26–32 years to study the relationship of maternal size, newborn size and trajectories of childhood growth to cardiovascular disease risk factors in these young South Indian adults.