Involvement of Nrf2 in Ocular Diseases.
Involvement of Nrf2 in Ocular Diseases.
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DOI：
10.1155/2017/1703810
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发表时间：
2017
影响因子：
--
通讯作者：
Pang IH
中科院分区：
文献类型：
--
作者：
Batliwala S;Xavier C;Liu Y;Wu H;Pang IH
人体内含有氧化剂和抗氧化剂之间复杂而微妙的平衡。这种制衡系统的任何破坏都可能导致各种器官和组织的有害后果，例如眼睛。本文综述了氧化应激的影响和一个特定的抗氧化系统的作用Keap 1-Nrf 2-ARE途径对眼部疾病，特别是年龄相关性黄斑变性，白内障，糖尿病视网膜病变和青光眼。它们是世界上致盲的主要原因。
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.