Visual categorization and the primate prefrontal cortex: Neurophysiology and behavior
Visual categorization and the primate prefrontal cortex: Neurophysiology and behavior
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DOI：
10.1152/jn.2002.88.2.929
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发表时间：
2002-08-01
影响因子：
2.5
通讯作者：
Miller, EK
中科院分区：
文献类型：
--
作者：
Freedman, DJ;Riesenhuber, M;Miller, EK
将刺激归类为有意义的类别的能力是一个基本的认知过程。为了探索其神经基础，我们训练猴子将计算机生成的刺激分类为“猫”和“狗”。“一个变形系统被用来系统地改变刺激的形状，并精确地定义一个类别的边界。心理物理测试和眼球运动分析表明，猴子通过关注多个刺激特征来对刺激进行分类。当一只猴子被重新训练时，同样的刺激被分配到新的类别，外侧前额叶皮层的神经元活动反映了视觉刺激的类别，并随着学习而改变。此外，许多神经元表现出的活动似乎反映了猴子对两种刺激是否来自同一类别的决定。这些结果表明，外侧前额叶皮质是类别学习和基于类别的行为的神经元回路的重要组成部分。
The ability to group stimuli into meaningful categories is a fundamental cognitive process. To explore its neuronal basis, we trained monkeys to categorize computer-generated stimuli as "cats" and "dogs." A morphing system was used to systematically vary stimulus shape and precisely define a category boundary. Psychophysical testing and analysis of eye movements suggest that the monkeys categorized the stimuli by attending to multiple stimulus features. Neuronal activity in the lateral prefrontal cortex reflected the category of visual stimuli and changed with learning when a monkey was retrained with the same stimuli assigned to new categories. Further, many neurons showed activity that appeared to reflect the monkey's decision about whether two stimuli were from the same category or not. These results suggest that the lateral prefrontal cortex is an important part of the neuronal circuitry underlying category learning and category-based behaviors.