San-Francisco/Oakland Bay Bridge welder study
San-Francisco/Oakland Bay Bridge welder study
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DOI：
10.1212/01.wnl.0000276988.50742.5e
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发表时间：
2007-09-18
期刊：
影响因子：
9.9
通讯作者：
Doty, Richard L.
中科院分区：
文献类型：
--
作者：
Antunes, Marcelo B.;Bowler, Rosemarie;Doty, Richard L.
背景：嗅觉可能会被空气中的异生物质（包括雾化重金属）损害，反映出其受体直接暴露于外部环境。目的：确定在密闭空间工作的专业焊工是否表现出嗅觉功能障碍。为了确定这种功能障碍（如果存在）是否与焊接相关的金属暴露指数以及神经和神经心理学功能测量有关。方法：对在旧金山/奥克兰海湾大桥工作了 1 至 2 年的 43 名焊工进行了宾夕法尼亚大学气味识别测试 (UPSIT) 和一系列神经学和神经心理学测试。获得了锰、铁、铜和铅的血液浓度。结果：相对于匹配的对照组，焊工的 UPSIT 分数显着较低，焊工的平均值 (SEM) 为 29.51 (0.90)，对照组为 36.55 (0.88)。百分之八十八的人得分低于他们各自匹配的对照组。与特发性帕金森病一样，根据主成分分析确定，焊工的嗅觉测试分数与广泛的神经学和神经心理学测试测量无关。尽管血液中锰的含量与在桥梁上工作的时间有关，但血液中锰含量最高的工人比血液中锰含量最低的工人表现出更好的嗅觉功能。先前观察到的这一悖论的基础尚不清楚。结论：专业焊工可能面临嗅觉功能丧失的风险，尽管这种丧失似乎与神经学和神经心理学测试表现无关。
Background: The sense of smell can be damaged by airborne xenobiotics, including aerosolized heavy metals, reflecting the direct exposure of its receptors to the outside environment.Objectives: To determine whether professional welders working in confined spaces exhibit olfactory dysfunction. To determine whether such dysfunction, if present, is related to indices of metal exposure associated with welding, as well as measures of neurologic and neuropsychological function.Methods: The University of Pennsylvania Smell Identification Test (UPSIT) and a battery of neurologic and neuropsychological tests were administered to 43 welders who worked for 1 to 2 years on the San Francisco/Oakland Bay Bridge. Blood levels of Mn, Fe, Cu, and Pb were obtained.Results: Relative to matched controls, the welders had significantly lower UPSIT scores, with a mean (SEM) of 29.51 (0.90) for welders and 36.55 (0.88) for controls. Eighty-eight percent scored below their individually matched controls. As in idiopathic Parkinson disease, the welders' olfactory test scores were unrelated to a broad spectrum of neurologic and neuropsychological test measures, as determined by principal components analysis. Although blood levels of Mn were associated with the time spent working on the bridge, workers with the highest Mn blood levels exhibited better olfactory function than those with the lowest Mn blood levels. The basis of this paradox, which has been observed previously, is unknown.Conclusions: Professional welders may be at risk for loss of smell function, although such loss seems to be unrelated to neurologic and neuropsychological test performance.