Genes, environment, and time: The Vietnam Era Twin Study of Aging (VETSA)
Genes, environment, and time: The Vietnam Era Twin Study of Aging (VETSA)
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DOI：
10.1375/twin.9.6.1009
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发表时间：
2006-12-01
影响因子：
0.9
通讯作者：
Lyons, Michael J.
中科院分区：
文献类型：
--
作者：
Kremen, William S.;Thompson-Brenner, Heather;Lyons, Michael J.
越南时代孪生衰老研究（VETSA）是一项针对中老年认知衰老的大规模调查。预期的 1440 名双胞胎受试者样本是从越南时代双胞胎登记处 (VETR) 中招募的，该登记处登记了在越南冲突 (1965-1975) 期间都在军队服役的中年男性对男性双胞胎。 VETSA 采用多特征多方法进行认知评估，重点关注随着时间的推移遗传和环境对认知过程的贡献，以及健康、社会、个性和其他背景因素对认知衰老的相对贡献。情景记忆、工作记忆、抽象推理和抑制执行功能的认知领域通过神经心理学测试进行评估。此外，VETSA 还会获取参与者在 20 岁左右入伍时的武装部队资格考试成绩，并重新进行考试。另外两个项目 - VETSA 皮质醇和 VETSA 磁共振成像 - 也在使用 VETSA 双胞胎的子样本进行中。 VETSA 调查人员使用 VETR 进行的前几波数据收集提供了有关身心健康的历史数据，而未来的 VETSA 数据收集浪潮计划每 5 年进行一次。这些方法将提供同一个体的多种表型数据，包括遗传和环境对认知功能随时间的影响、个性和人际风险和保护因素、压力和皮质醇调节以及衰老过程的结构性大脑相关性。
The Vietnam Era Twin Study of Aging (VETSA) is a large-scale investigation of cognitive aging from middle to later age. The intended sample of 1440 twin subjects is recruited from the Vietnam Era Twin Registry (VETR), a registry of middle-aged male-male twin pairs who both served in the military during the Vietnam conflict (1965-1975). VETSA employs a multitrait multimethod approach to cognitive assessment to focus on the genetic and environmental contributions to cognitive processes over time, as well as the relative contributions to cognitive aging from health, social, personality, and other contextual factors. The cognitive domains of episodic memory, working memory, abstract reasoning, and inhibitory executive functioning are assessed through neuropsychological testing. In addition, VETSA obtains the participant's score on the Armed Forces Qualification Test, taken at the time of induction into the military around age 20 years, and readministers the test. Two other projects - VETSA Cortisol and VETSA Magnetic Resonance Imaging - are also in progress using subsamples of the VETSA twins. Prior waves of data collection by VETSA investigators using the VETR have provided historical data on physical and mental health, while future waves of VETSA data collection are planned every 5 years. These methods will provide data on multiple phenotypes in the same individuals with regard to genetic and environmental contributions to cognitive functioning over time, personality and interpersonal risk and protective factors, stress and cortisol regulation, and structural brain correlates of aging processes.