E-cadherin expression in canine cutaneous histiocytomas
E-cadherin expression in canine cutaneous histiocytomas
复制标题
DOI：
10.1136/vr.162.16.509
复制
发表时间：
2008-04-19
影响因子：
2.2
通讯作者：
McConnell, I.
中科院分区：
文献类型：
--
作者：
Baines, S. J.;Mcinnes, E. F.;McConnell, I.
犬皮肤组织细胞瘤是一种常见的皮肤朗格汉斯细胞源性肿瘤。朗格汉斯细胞是抗原呈递细胞的树突状细胞家族的成员，位于表皮中。它们在树突状细胞谱系中是独特的，因为它们表达高水平的粘附分子E-钙粘蛋白。应用流式细胞术和免疫组织化学方法，对37例犬皮肤组织细胞瘤瘤样郎格罕细胞中E-钙粘素的表达进行了研究。在所有病例中，这些细胞表达E-钙粘蛋白，而浸润淋巴细胞不表达。
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. in all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.