Endotoxin-transport routes and kinetics in intestinal ischemia.
Endotoxin-transport routes and kinetics in intestinal ischemia.
复制标题
肠道缺血中的内毒素转运途径和动力学。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
P. Olsson
中科院分区：
文献类型：
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作者：
P. Olofsson;G. Nylander;P. Olsson
采用大鼠节段性肠缺血模型，研究缺血肠段内毒素的吸收和转运。对腹腔液、胸导管淋巴液、动、门静脉血进行系列定量分析。透壁渗漏发生前，胸导管淋巴液内毒素浓度明显升高。内毒素通过失活肠壁渗漏后，经淋巴和门静脉途径转运。动力学分析表明，全身性内毒素血症导致胸导管淋巴内毒素的出现，在门静脉内毒素显著增加之前。门静脉转运的量从未超过肝脏的内毒素过滤能力。因此，在肠缺血时，全身性内毒素血症似乎主要由淋巴转运介导。
A rat model representing segmental intestinal ischemia was used to study the absorption and transport of endotoxin from the ischemic gut. Serial quantitative analyses were made on peritoneal fluid, thoracic duct lymph and arterial and portal vein blood. Significantly increased endotoxin concentrations were found in thoracic duct lymph before transmural leakage took place. After leaking through the devitalized intestinal wall, endotoxin was transported by both lymphatic and portal routes. Kinetic analysis revealed that systemic endotoxemia paralleled the appearance of endotoxins in thoracic duct lymph, preceding a significant increase in the portal vein. The amount transported by the portal vein never exceeded the proposed endotoxin-filtrating capacity of the liver. In intestinal ischemia, consequently, systemic endotoxemia appears to be mediated mainly by lymphatic transport.