Faecal microbiota transplantation protects against radiation-induced toxicity.
Faecal microbiota transplantation protects against radiation-induced toxicity.
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粪便微生物群移植可防止辐射引起的毒性。
DOI：
10.15252/emmm.201606932
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发表时间：
2017-04
影响因子：
11.1
通讯作者：
Fan S
中科院分区：
文献类型：
--
作者：
Cui M;Xiao H;Li Y;Zhou L;Zhao S;Luo D;Zheng Q;Dong J;Zhao Y;Zhang X;Zhang J;Lu L;Wang H;Fan S
严重的辐射暴露可能导致急性辐射综合症，这是一种可能致命的疾病，需要有效的治疗。通过控制肠道菌群可以对抗许多疾病。我们探讨了肠道微生物移植是否可以减轻辐射引起的毒性。高通量测序显示，雄性和雌性小鼠的胃肠道细菌群落组成不同，并与辐射毒性易感性有关。粪便微生物群移植（FMT）提高了受辐射动物的存活率，提高了外周白细胞计数，改善了受辐射雄性和雌性小鼠的胃肠道功能和肠上皮的完整性。FMT保留了肠道细菌组成，并以性别特异性的方式保留了宿主小肠的mRNA和长链非编码RNA表达谱。尽管促进了血管生成，但性别匹配的FMT在体内并没有加速癌细胞的增殖。FMT可能作为一种治疗方法来减轻放射诱导的毒性，改善肿瘤患者放疗后的预后。
Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. Despite promoting angiogenesis, sex‐matched FMT did not accelerate the proliferation of cancer cells in vivo. FMT might serve as a therapeutic to mitigate radiation‐induced toxicity and improve the prognosis of tumour patients after radiotherapy.