Does the Influence of Childhood Adversity on Psychopathology Persist Across the Lifecourse? A 45-Year Prospective Epidemiologic Study
Does the Influence of Childhood Adversity on Psychopathology Persist Across the Lifecourse? A 45-Year Prospective Epidemiologic Study
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DOI：
10.1016/j.annepidem.2010.02.008
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发表时间：
2010-05-01
影响因子：
5.6
通讯作者：
Stansfeld, Stephen A.
中科院分区：
文献类型：
--
作者：
Clark, Charlotte;Caldwell, Tanya;Stansfeld, Stephen A.
目得：关于童年期逆境和精神病理学之间的联系是否在整个生命过程中减弱以及对中年精神病理学的影响是否通过青少年和成年早期精神病理学介导的前瞻性证据是有限的。数据来自1958年英国出生队列，这是一项为期45年的研究，1958年在英格兰，苏格兰，和威尔士结果包括45岁时情感和焦虑障碍的国际疾病统计分类（ICD-10）诊断以及16岁和23岁时的精神病理学诊断。在7岁、11岁和16岁时可获得儿童逆境的多个多信息源测量，在45岁时对父母的性虐待和身体虐待进行额外的回顾性测量。分析是在N = 9377的基础上确定的; 59%的存活样本结果：在调整社会经济协变量后，儿童期逆境与青少年、成年早期和中年精神病理学有关，大多数相关性不随年龄而减弱中年相关性显著地完全或部分地由成年早期的精神病理学累积的逆境、疾病、性虐待和身体虐待介导，仍然与中年精神病理学显著相关。研究结果证实了预防暴露于逆境的重要性，并表明逆境对中期的影响。生活精神病理学可能通过成年早期的精神病理学起作用。未来的研究需要检查其他可能解释这些联系的中介因素。2010，20 385-394. (C)2010年爱思唯尔公司版权所有
PURPOSE: Prospective evidence about whether the association of childhood adversity and psychopathology attenuates across the lifecourse and whether effects on mid-life psychopathology are mediated through adolescent and early adulthood psychopathology is limitedMETHODS: Data were from the 1958 British Birth Cohort, a 45-year study of 9896 of births in 1 week in 1958 in England, Scotland, and Wales Outcomes included International Statistical Classification of Diseases (ICD-10) diagnoses for affective and anxiety disorders at 45 years and psychopathology at 16 years and 23 years Multiple multi-informant measures of childhood adversity were available at 7, 11, and 16 years, with additional retrospective measures of parental sexual and physical abuse at 45 years Analyses were determined on the basis of N = 9377; 59% of the surviving sampleRESULTS: After adjustment for socioeconomic covariates, childhood adversities were associated with adolescent, early adulthood, and mid-life psychopathology, most associations did not attenuate with age Mid-life associations were significantly fully or partially mediated by early adulthood psychopathology cumulative adversity, Illness, sexual abuse, and physical abuse remained significantly associated with mid-life psychopathologyCONCLUSIONS: The findings confirm the importance of preventing exposure to adversity and suggest that effects of adversity on mid-life psychopathology may operate through psychopathology in early adulthood Future research is needed to examine other intermediary factors which may explain these associations Ann Epidemiol 2010, 20 385-394. (C) 2010 Elsevier Inc. All rights reserved