Neuronal substrates of sensory gating within the human brain
Neuronal substrates of sensory gating within the human brain
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DOI：
10.1016/s0006-3223(02)01673-6
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发表时间：
2003-03-15
影响因子：
10.6
通讯作者：
Elger, CE
中科院分区：
文献类型：
--
作者：
Grunwald, T;Boutros, NN;Elger, CE
背景：对于人脑来说，对不相关的感觉输入的习惯是一项重要的功能，其失败与行为障碍有关。感觉门控可以通过记录大脑对重复点击声的电反应来研究：P50 电位通常会降低到两次配对点击声中的第二次，但精神分裂症患者不会。为了确定其神经相关性，我们直接记录了人类海马和新皮质的感觉门控电迹。方法：使用海马深度电极以及硬膜下条带和网格电极记录 32 名接受侵入性术前评估的癫痫患者的颅内诱发电位。结果：我们仅在海马、颞顶叶区（布罗德曼区 22）发现感觉门控的证据。和 2) 以及前额皮质（布罗德曼区 6 和 24）；然而，虽然新皮质对配对点击的习惯性反应在 50 毫秒左右达到峰值，但海马体内部的反应有约 250 毫秒的潜伏期。结论：与动物研究的数据一致，我们的研究结果表明，海马体本身有助于感觉门控，尽管是在新皮质习惯化过程之后的一个时间窗口内。因此，感觉门控可能是一个多步骤的过程，早期阶段由颞顶叶和前额叶皮层促进，后期阶段由海马体介导。 (C) 2003年生物精神病学学会
Background: For the human brain, habituation to irrelevant sensory input is an important function whose failure is associated with behavioral disturbances. Sensory gating can be studied by recording the brain's electrical responses to repeated clicks: the P50 potential is normally reduced to the second of two paired clicks but not in schizophrenia patients. To identify its neural correlates, we recorded electrical traces of sensory gating directly from the human hippocampus and neocortex.Methods: Intracranial evoked potentials were recorded using hippocampal depth electrodes and subdural strip and grid electrodes in 32 epilepsy patients undergoing invasive presurgical evaluation.Results: We found evidence of sensory gating only in the hippocampus, the temporo-parietal region (Brodmann's areas 22 and 2), and the prefrontal cortex (Brodmann's areas 6 and 24); however, whereas neocortical habituating responses to paired clicks were peaking around 50 msec, responses within the hippocampus proper had a latency of about 250 msec.Conclusions: Consistent with data from animal studies, our findings show that the hippocampus proper contributes to sensory gating, albeit during a time window following neocortical habituation processes. Thus, sensory gating may be a multistep process, with an early phase subserved by the temporo-parietal and prefrontal cortex and a later phase mediated by the hippocampus. (C) 2003 Society of Biological Psychiatry