B-cell lymphocyte kinase polymorphisms rs13277113, rs2736340, and rs4840568 and risk of autoimmune diseases: A meta-analysis.
B-cell lymphocyte kinase polymorphisms rs13277113, rs2736340, and rs4840568 and risk of autoimmune diseases: A meta-analysis.
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B 细胞淋巴细胞激酶多态性 rs13277113、rs2736340 和 rs4840568 与自身免疫性疾病的风险：一项荟萃分析。
DOI：
10.1097/md.0000000000007855
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发表时间：
2017-09
期刊：
影响因子：
1.6
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Zeng C;Fang C;Weng H;Xu X;Wu T;Li W
B细胞淋巴细胞激酶（BLK）是B细胞的抑制剂，对多种自身免疫性疾病有重要影响，但目前缺乏对其与自身免疫性疾病相关性的全面分析。因此，进行全面的分析是有意义的。在PubMed、ScienceDirect和Web of Science数据库中进行了系统性文献检索，检索截止日期为2016年6月30日。在进行荟萃分析之前，对数据进行了提取和质量评估。用STATA 12.0版软件评估比值比（OR）和95%置信区间（95% CI）。进行亚组和敏感性分析，以探索异质性的潜在来源。总共有33项研究（68,874例和90,684例对照），24项研究（31,095例和39,077例对照），21项研究（26,388例和40,635例对照），4项研究（11,391例和10例对照），本荟萃分析纳入了972例rs 4840568对照。结果显示BLK rs 13277113和rs 2736340多态性增加了自身免疫性疾病的风险（A vs G：OR = 1.33，95%CI = 1.27-1.39，P <.01; T vs C：OR = 1.34，95%CI = 1.27-1.41，P <.01），rs 4840568与系统性红斑狼疮（SLE）正相关（A vs G：OR = 1.32，95%CI = 1.22-1.43，P =.01）。 这项荟萃分析表明，BLK（rs 13277113，rs 2736340，rs 4840568）多态性可能是发生自身免疫性疾病的危险因素，特别是在亚洲人群和SLE。
Supplemental Digital Content is available in the text B-cell lymphocyte kinase (BLK) is an inhibitor of B cells that has an important influence on several autoimmune diseases, but there is a lack of comprehensive analysis of its association with autoimmune diseases. Hence, it is meaningful to conduct a comprehensive analysis. A systematic literature search was performed on the PubMed, ScienceDirect, and Web of Science databases up to June 30, 2016. The data were extracted and quality-assessed before conducting the meta-analysis. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were assessed with the STATA version 12.0 software. Subgroup and sensitivity analysis were conducted to explore potential sources of heterogeneity. Altogether, 33 studies with 68,874 cases and 90,684 controls, 24 studies with 31,095 cases and 39,077 controls for rs13277113, 21 studies with 26,388 cases and 40,635 controls for rs2736340, and 4 studies with 11,391 cases and 10,972 controls for rs4840568 were included in this meta-analysis. The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27–1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27–1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22–1.43, P = .01). This meta-analysis shows that the BLK (rs13277113, rs2736340, rs4840568) polymorphisms may be a risk factor for developing autoimmune diseases, especially for Asian populations and SLE.