Feasibility of simultaneous temperature and tissue stiffness detection by MRE
Feasibility of simultaneous temperature and tissue stiffness detection by MRE
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DOI：
10.1002/mrm.20801
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Felmlee, JP
中科院分区：
文献类型：
--
作者：
Le, Y;Glaser, K;Felmlee, JP
温度和组织硬度是可用于监测MRI引导的聚焦超声热疗的两个指标。在热疗过程中同时使用这两种方法来监测治疗进展将是有益的。磁共振弹性成像(MRE)已经被证明可以提供组织硬度信息；这项工作的目的是演示如何从相同的MRE数据采集中得出温度。MRE数据来自1.5%琼脂糖模和体外猪肌肉组织(来自杂货店)，同时缓慢加热。用荧光温度计测量温度。利用MRE采集的相位平均值来计算与温度变化相关的质子共振频率漂移引起的相移。结果表明，由磁共振仪提取的温度引起的相移与温度计记录的温度变化具有很好的相关性，琼脂糖模的温度系数为-0.0096 ppm/℃，而体外猪组织的温度系数为-0.0103 ppm/℃。这些结果表明，使用一种新的MRE数据重建方法可以同时测量温度和组织剪切刚度。Magn Reson Med 55：700-705,2006。(C)2006年Wiley-Liss，Inc.
Temperature and tissue stiffness are two indices that can be used to monitor MRI-guided focused ultrasound thermal therapy. It would be beneficial to have both measures available to monitor treatment progression during thermal therapy. MR Elastography (MRE) has already been shown to provide tissue stiffness information; the purpose of this work is to demonstrate how temperature can be derived from the same MRE data acquisition. MRE data were acquired from 1.5% agarose phantoms and ex vivo porcine muscle tissue (from a grocery store) while they were heated slowly. The temperatures were measured using a fluorescent thermometer. The phase average from the MRE acquisition was used to calculate the phase shift induced by the proton resonance frequency shift associated with the temperature change. The results show that the phase shift due to temperature extracted from MRE data correlate well with the temperature change recorded by thermometer, yielding a temperature coefficient of -0.0096 ppm/degrees C for the agarose phantom, and -0.0103 ppm/degrees C for the ex vivo porcine tissue. These results indicate that it is possible to simultaneously measure both temperature and tissue shear stiffness using anew method of MRE data reconstruction. Magn Reson Med 55:700-705, 2006. (c) 2006 Wiley-Liss, Inc.