Role of Imaging in Clinical Islet Transplantation
Role of Imaging in Clinical Islet Transplantation
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DOI：
10.1148/rg.302095741
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发表时间：
2010-03-01
期刊：
影响因子：
5.5
通讯作者：
Shapiro, A. M. James
中科院分区：
文献类型：
--
作者：
Low, Gavin;Hussein, Nassrein;Shapiro, A. M. James
胰岛移植是1型糖尿病患者的一种创新和有效的临床策略，即使使用最积极的药物治疗方案，其临床状况也无法得到充分管理。在胰岛移植中，从死亡供体的胰腺中提取的纯化的胰岛被注入受体肝脏的门静脉。移植的胰岛产生胰岛素，从而恢复许多患者的健康。采用最初的埃德蒙顿方案进行胰岛移植后，80%的患者在1年时不依赖胰岛素，约20%的患者在5年时不依赖胰岛素。随着最近的技术进步，50%或更多的患者在胰岛移植后5年保持胰岛素依赖性。随着时间的推移，单供体胰岛输注的成功率显著提高。即使在失去胰岛素依赖性的患者中，胰岛移植也被认为是成功的，因为它提供了改善的血糖控制和更高的生活质量。影像学在胰岛移植中起着重要的作用，通常用于评估潜在的受体，指导移植过程，并监测患者的移植后并发症。由于胰岛移植的成功及其在世界范围内的日益普及，熟悉成像的作用是很重要的。（C）RSNA，2010.radiographics.rsna.org
Islet transplantation is an innovative and effective clinical strategy for patients with type 1 diabetes whose clinical condition is inadequately managed even with the most aggressive medical treatment regimens. In islet transplantation, purified islets extracted from the pancreas of deceased donors are infused into the portal vein of the recipient liver. Engrafted islets produce insulin and thus restore euglycemia in many patients. After islet transplantation performed with the original Edmonton protocol, 80% of patients were insulin independent at 1 year and approximately 20% were insulin independent at 5 years. With more recent technical advances, 50% of patients or more maintain insulin independence 5 years after islet transplantation. The success rate with single-donor islet infusions has markedly improved over time. Even in patients who lose insulin independence, islet transplantation is considered successful because it provides improved glycemic control and a higher quality of life. Imaging plays an important role in islet transplantation and is routinely used to evaluate potential recipients, guide the transplantation process, and monitor patients for posttransplantation complications. Because of the success of islet transplantation and its increasing availability worldwide, familiarity with the role of imaging is important. (C)RSNA, 2010.radiographics.rsna.org