Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements.
Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements.
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由于收缩活动和氨基酸可用性而控制肌肉蛋白质合成：对蛋白质需求的影响。
DOI：
10.1123/ijsnem.11.s1.s170
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发表时间：
2001
影响因子：
2.5
通讯作者：
M. Rennie
中科院分区：
文献类型：
--
作者：
M. Rennie
对肌肉的主要合成代谢影响是摄食和收缩活动。作为摄食的结果，主要通过蛋白质合成的增加和蛋白质分解的微小变化来发生厌食症。胰岛素在增加合成方面具有许可作用，但氨基酸的可用性对于净合成代谢至关重要。我们已经研究了氨基酸在刺激肌肉蛋白质合成中的作用，运动和氨基酸可用性之间的协同作用，以及一些相关的信号元件。结果表明，肌肉对氨基酸非常敏感，运动可能通过单独的途径增加氨基酸的合成代谢作用，因此，习惯的体育锻炼不太可能增加蛋白质的需求。
The major anabolic influences on muscle are feeding and contractile activity. As a result of feeding, anabolism occurs chiefly by increases in protein synthesis with minor changes in protein breakdown. Insulin has a permissive role in increasing synthesis, but the availability of amino acids is crucial for net anabolism. We have investigated the role of amino acids in stimulating muscle protein synthesis, the synergy between exercise and amino acid availability, and some of the signaling elements involved. The results suggest that muscle is acutely sensitive to amino acids, that exercise probably increases the anabolic effects of amino acids by a separate pathway, and that for this reason it is unlikely that accustomed physical exercise increases protein requirements.