The epidemiology of diabetes in Swedish children 0–14 years — a six-year prospective study
The epidemiology of diabetes in Swedish children 0–14 years — a six-year prospective study
复制标题
瑞典 0-14 岁儿童糖尿病流行病学——一项为期六年的前瞻性研究
作者：
G. Dahlquist;L. Blom;G. Holmgren;B. Hägglöf;Y. Larsson;G. Sterky;Stig Wall
自1977年7月1日以来，瑞典所有新诊断的0-14岁糖尿病儿童都被报告到一个中央登记处。在最初的6年中，在160万儿童人口中登记了2300名新诊断的糖尿病儿童。确定度接近100%。6年期间的年平均发病率为23.6 / 100000。1980年7月1日胰岛素依赖型糖尿病患病率为1.48 / 1000,1983年7月1日为1.52 / 1000。比较第一个和第二个三年期，发现增加（22.7-25.1 / 100000）。在按年龄、性别和地理分布分析发病率时，这种增加是一致的。累积发病率显示，到15岁时，男孩患糖尿病的风险为千分之3.6，女孩为千分之3.2。在整个研究期间，男孩的高发病率是一致的。发病率的季节变化也一致，每年的发病率在秋季和冬季达到高峰。男女发病高峰均出现在青春期。在全国范围内，年龄和性别标准化的发病率差别很大。12.8%的先证者有一级亲属患有1型糖尿病，该亲属为父亲的比例是母亲的两倍。在遗传稳定的人群中，如瑞典，1型糖尿病的高发病率和快速增长要求进行病例对照研究，以确定环境病原体。
SummarySince 1 July 1977, all newly diagnosed diabetic children in Sweden aged 0–14 years have been reported to a central register. During the first 6 years, 2300 newly diagnosed diabetic children out of a population of 1.6 million children were registered. The degree of certainty was close to 100%. The mean of the yearly incidence rate for the whole 6 year period was 23.6 per 100000. The prevalence of insulin dependent diabetes mellitus on 1 July 1980 was 1.48 per 1000 and 1.52 on 1 July 1983. Comparing the first and second 3-year periods, an increase was found (22.7–25.1 per 100000). This increase was consistent when analyzing incidence rates by age, sex, and geographical distribution. Cumulative incidence rates revealed a risk of developing diabetes by the age of 15 years of 3.6 per thousand for boys and 3.2 per thousand for girls. The higher incidence for boys was consistent throughout the study period. Seasonal variations in the incidence rate were also consistent, showing yearly incidence peaks in the autumn and winter months. Incidence peaks were noted for both sexes in the pubertal ages. Age- and sex-standardized morbidity ratios varied significantly within the country. 12.8% of the probands had a first degree relative with Type 1 diabetes, and it was twice as common that this relative was a father as a mother. The high and rapidly increasing incidence of Type 1 diabetes in a genetically stable population such as Sweden calls for case-control studies directed towards the identification of environmental pathogens.