The effect of prolonged decompaction on the development of the preimplantation mouse embryo.
The effect of prolonged decompaction on the development of the preimplantation mouse embryo.
复制标题
长时间解压对植入前小鼠胚胎发育的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
P. Stern
中科院分区：
文献类型：
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作者：
M. Johnson;J. Chakraborty;A. Handyside;K. Willison;P. Stern
小鼠胚胎癌细胞系的兔抗血清可阻断小鼠胚胎的压实。细胞分裂不受影响，直到32个细胞阶段，但细胞内连接不能发育。在这一阶段去除抗体允许压实发生，正常囊胚发育。超过32个细胞的胚胎长时间的脱压导致畸形囊胚的比例增加，其中滋养外胚层细胞占主导地位，功能内细胞团（ICM）细胞减少或缺失。讨论了压实作用与完整胚中ICM和滋养外胚层世系发生的关系。
A rabbit antiserum to a mouse embryonal carcinoma cell line blocks compaction of cleaving mouse embryos. Cell division is not affected up to the 32-cell stage but intracellular junctions fail to develop. Removal of the antibody at this stage permits compaction to occur and a normal blastocyst develops. Prolonged decompaction beyond the 32-cell embryo results in an increasing proportion of malformed blastocysts in which trophectodermal cells predominate and functional inner cell mass (ICM) cells are reduced or absent. The relationship of compaction to the generation of ICM and trophectoderm lineages in the intact embryo is discussed.