IMMUNITY TO AND FREQUENCY OF REINFECTION WITH RESPIRATORY SYNCYTIAL VIRUS
IMMUNITY TO AND FREQUENCY OF REINFECTION WITH RESPIRATORY SYNCYTIAL VIRUS
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DOI：
10.1093/infdis/163.4.693
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发表时间：
1991-04-01
影响因子：
6.4
通讯作者：
SCHNABEL, KC
中科院分区：
文献类型：
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作者：
HALL, CB;WALSH, EE;SCHNABEL, KC
为了更好地了解针对呼吸道合胞病毒（RSV）的免疫持续时间以及血清中针对表面糖蛋白F和G的抗体在再次感染易感性中的作用，15名既往有自然RSV感染史的成年人在自然感染后的2、4、8、14、20和26个月时，用同一毒株组（A）的RSV进行激发。到2个月时，约一半的受试者再次感染，到8个月时，三分之二的受试者再次感染。每次激发至少导致四分之一的受试者感染。在26个月内，73%的受试者有两次或更多次感染，47%的受试者有三次或更多次感染。在两次间隔较短的感染之后，免疫持续时间有延长的趋势。激发前较高的中和抗体、F抗体和G（A）抗体水平与抗感染保护作用显著相关。然而，即使在抗体水平最高的受试者中，再次感染的风险仍为25%。特异性鼻IgA抗体滴度与保护作用无显著相关性。这表明体液中和抗体、F抗体和G抗体与再次感染的抵抗力相关，但保护作用远非完全，且持续时间较短。
To better understand the duration of immunity against respiratory syncytial virus (RSV) and the role of serum antibodies to the surface glycoproteins, F and G, in susceptibility to reinfection, 15 adults with previous natural RSV infection were challenged with RSV of the same strain group (A) at 2, 4, 8, 14, 20, and 26 months after natural infection. By 2 months about one-half and by 8 months two-thirds of the subjects became reinfected. Each challenge resulted in infection in at least one-fourth of the subjects. Within 26 months 73% had two or more and 47% had three or more infections. The duration of immunity tended to increase after two closely spaced infections. Higher neutralizing, F and G(A) antibody levels before challenge correlated significantly with protection against infection. However, even in subjects with the highest antibody levels, the risk of reinfection was 25%. Specific nasal IgA antibody titers did not correlate significantly with protection. This suggests that humoral neutralizing, F, and G antibodies correlate with resistance to reinfection, but protection is far from complete and is of short duration.