Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer.
Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer.
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DOI：
10.1158/0008-5472.can-21-2522
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发表时间：
2022-04-01
期刊：
影响因子：
11.2
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中科院分区：
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有一个尚未得到满足的需求，即确定和验证肿瘤特异性治疗靶点，以实现更有效的癌症治疗。患者临床特征的异质性以及肿瘤的生物学和遗传学特征给优化治疗干预措施带来了重大挑战，包括开发新的和更有效的精确医学。角蛋白17(K17)的表达是最具侵袭性的癌症的标志，涉及广泛的解剖部位和组织类型。K17与较短的患者生存期相关，预测对特定化疗药物的耐药性，并具有提示其可以作为治疗靶点的功能域。在这里，我们探索K17在癌症特征中的作用，并总结迄今涉及每个特征的K17介导机制的证据，阐明值得进一步研究的功能角色，以指导新的治疗策略的发展。
There is an unmet need to identify and validate tumor-specific therapeutic targets to enable more effective treatments for cancer. Heterogeneity in patient clinical characteristics as well as biological and genetic features of tumors present major challenges for the optimization of therapeutic interventions, including the development of novel and more effective precision medicine. The expression of keratin 17 (K17) is a hallmark of the most aggressive forms of cancer across a wide range of anatomical sites and histological types. K17 correlates with shorter patient survival, predicts resistance to specific chemotherapeutic agents, and harbors functional domains that suggest it could be therapeutically targeted. Here, we explore the role of K17 in the hallmarks of cancer and summarize evidence to date for K17-mediated mechanisms involved in each hallmark, elucidating functional roles that warrant further investigation to guide the development of novel therapeutic strategies.